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Clinical features of pulmonary cryptococcosis in non-HIV patients in Japan
http://hdl.handle.net/10069/35900
http://hdl.handle.net/10069/359000341606f-e474-4672-a4c8-f71cdd8b7f38
名前 / ファイル | ライセンス | アクション |
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JIC21_23.pdf (427.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-10-21 | |||||
タイトル | ||||||
タイトル | Clinical features of pulmonary cryptococcosis in non-HIV patients in Japan | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Computed tomography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cryptococcal antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immune status | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Meningoencephalitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-HIV patient | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary cryptococcosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kohno, Shigeru
× Kohno, Shigeru× Kakeya, Hiroshi× Izumikawa, Koichi× Miyazaki, Taiga× Yamamoto, Yoshihiro× Yanagihara, Katsunori× Mitsutake, Kotaro× Miyazaki, Yoshitsugu× Maesaki, Shigefumi× Yasuoka, Akira× Tashiro, Takayoshi× Mine, Mariko× Uetani, Masataka× Ashizawa, Kazuto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVE: To clarify the clinical features of pulmonary cryptococcosis in Japanese non-HIV population. METHODS: Retrospective investigation of 151 pulmonary cryptococcosis cases between 1977 and 2012 was executed. The underlying disease (UDs), aggravating factors, radiological characteristics, and treatment were examined. RESULTS: Sixty-seven patients (44.4%) had no UDs. The common UDs were diabetes (32.1%) followed by hematologic disease (22.6%), and collagen disease (22.6%). Peripherally distributed pulmonary nodules/masses were most commonly seen. Lesions in the right middle lobe (p = 0.01) and air bronchogram (P = 0.05) were significantly more frequent, respectively, in patients with UDs than patients without them. Azoles were mainly selected for the patients without meningoencephalitis. Mean treatment duration for patients with and without UDs was 6.64 and 2.87 months, respectively. Patients whose pulmonary nodules improved after treatment continued to experience gradual reduction of cryptococcosis antigen titers, even if antigen titers were positive at the time of treatment cessation. The average time for antigen titers to become negative after treatment cessation was 13.1 and 10.7 months for patients with and without UDs, respectively. When groups were compared according to the presence of meningoencephalitis complications, deaths, and survivals, factors contributing to cryptococcosis prognosis included higher age, hypoproteinemia, hypoalbuminemia, steroid use, high C-reactive protein levels, and meningoencephalitis complications. CONCLUSIONS: It is crucial to consider the presence of UDs and meningoencephalitis for the choice of antifungals and treatment duration for cryptococcosis in non-HIV patients. Three- and six months-administration of azoles for pulmonary cryptococcosis with or without UDs, respectively is reasonable. |
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書誌情報 |
Journal of Infection and Chemotherapy 巻 21, 号 1, p. 23-30, 発行日 2015-01 |
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出版者 | ||||||
出版者 | 日本化学療法学会・日本感染症学会 | |||||
出版者別言語 | ||||||
Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341321X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jiac.2014.08.025 | |||||
権利 | ||||||
権利情報 | c 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Journal of infection and chemotherapy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of infection and chemotherapy, 21, 1, (2015) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Infection and Chemotherapy, 21(1), pp.23-30; 2015 |