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The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women
http://hdl.handle.net/10069/35975
http://hdl.handle.net/10069/35975745835f4-bb41-4e77-a842-7a72eaf945fd
名前 / ファイル | ライセンス | アクション |
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ISYK777_Ikeoka.pdf (381.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2015-11-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atherosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dyslipidemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tribbles homolog 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Triglyceride | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
池岡, 俊幸
× 池岡, 俊幸 |
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著者別名 | ||||||
姓名 | Ikeoka, Toshiyuki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent genome-wide association studies have identified Tribbles homolog 1 (TRIB1) as one of the candidate genes associated with lipid profiles. TRIB1 is known to interact with MAP kinases, thereby regulating their activities. The single nucleotide polymorphism rs2954029 of TRIB1 is located within an intron and is associated with lipid profiles. The aim of the present study is to investigate the TRIB1 rs2954029 (A>T polymorphism) with conventional predictors of coronary artery diseases such as carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI), and with lipid profiles in general population. This study enrolled 2,581 Japanese adults, 942 men and 1,639 women with a median age of 68 years (range 29 to 94 years), who participated in a screening program for the general population living in Goto City, Nagasaki Prefecture, Japan from 2008 to 2010. For the determination of TRIB1 rs2954029 genotypes, the polymerase chain reaction method was used. The differences in each parameter among the TRIB1 rs2954029 genotypes were evaluated using analysis of covariance. Genotype frequencies of TRIB1 rs2954029 in all participants were 25.5% for AA, 50.4% for AT, and 24.0% for TT. In women, the AA genotype showed significantly higher log triglyceride (TG) concentrations than the AT genotype (P = 0.004) and the AT + TT genotypes (P = 0.004). On the other hand, there were no associations with CIMT and CAVI among the TRIB1 rs2954029 genotypes. In conclusion, the TRIB1 rs2954029 is associated with serum TG concentrations in Japanese community-dwelling women. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第777号 学位授与年月日:平成27年3月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Toshiyuki Ikeoka, Naomi Hayashida, Mio Nakazato, Takaharu Sekita, Fumi Murata-Mori, Takao Ando, Norio Abiru, Hironori Yamasaki, Takashi Kudo, Takahiro Maeda, Atsushi Kawakami, Noboru Takamura | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: The Tohoku Journal of Experimental Medicine, 233(2), pp.149-153; 2014 | |||||
書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 233, 号 2, p. 149-153, 発行日 2015-03-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13493329 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.233.149 | |||||
権利 | ||||||
権利情報 | c 2014 Tohoku University Medical Press. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 日本人一般住民女性においてTribbles Homolog 1の遺伝子多型は血清中性脂肪値と関連する | |||||
出版者 | ||||||
出版者 | 東北ジャーナル刊行会 | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/35655 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2015-03-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第777号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2015-03-20) |