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Carbenoxolone-sensitive and cesium-permeable potassium channel in the rod cells of frog taste discs
http://hdl.handle.net/10069/35993
http://hdl.handle.net/10069/359937c35f884-81a4-47bf-9400-99b09a4c4302
名前 / ファイル | ライセンス | アクション |
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BBR4_175.pdf (623.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-11-30 | |||||
タイトル | ||||||
タイトル | Carbenoxolone-sensitive and cesium-permeable potassium channel in the rod cells of frog taste discs | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carbenoxolone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cs+-permeable | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lithobates catesbeianus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rod cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Taste disc | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Voltage-gated K+ channel | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Okada, Yukio
× Okada, Yukio× Miyazaki, Toshihiro× Fujiyama, Rie× Toda, Kazuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The rod cells in frog taste discs display the outward current and maintain the negative resting potential in the condition where internal K+ is replaced with Cs+. We analyzed the properties of the Cs+-permeable conductance in the rod cells. The current-voltage (I/V) relationships obtained by a voltage ramp were bell-shaped under Cs+ internal solution. The steady state I/V relationships elicited by voltage steps also displayed the bell-shaped outward current. The activation of the current accelerated with the depolarization and the inactivation appeared at positive voltage. The gating for the current was maintained even at symmetric condition (Cs+ external and internal solutions). The wing cells did not show the properties. The permeability for K+ was a little larger than that for Cs+. Internal Na+ and NMDG+ could not induce the bell-shaped outward current. Carbenoxolone inhibited the bell-shaped outward Cs+ current dose dependently (IC50: 27μM). Internal arachidonic acid (20μM) did not induce the linear current-voltage (I-V) relationship which is observed in two-pore domain K+ channel (K2P). The results suggest that the resting membrane potentials in the rod cells are maintained by the voltage-gated K+ channels. | |||||
書誌情報 |
Biochemistry and Biophysics Reports 巻 4, p. 175-179, 発行日 2015-12 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 24055808 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrep.2015.09.010 | |||||
権利 | ||||||
権利情報 | c 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biochemistry and Biophysics Reports, 4, pp.175-179; 2015 |