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Cis- and cell-type-dependent trans-requirements for Lassa virus-like particle production
http://hdl.handle.net/10069/36002
http://hdl.handle.net/10069/36002484935ef-5a0f-4371-8869-b11295138753
名前 / ファイル | ライセンス | アクション |
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JGV96_1626.pdf (598.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-08-01 | |||||
タイトル | ||||||
タイトル | Cis- and cell-type-dependent trans-requirements for Lassa virus-like particle production | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Urata, Shuzo
× Urata, Shuzo× Yasuda, Jiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lassa virus (LASV) small zinc-finger protein (Z), which contains two L-domain motifs, plays a central role in virus budding. Here, we report that co-expression of glycoprotein (GPC) altered the requirements for cholesterol but not the L-domains and host factor, Tsg101, for Z-induced virus-like particle (VLP) production. In particular, the cholesterol requirement for VLP production was cell-type-dependent. In addition, GPC was found to be important for co-localization of Z with CD63, a late endosomal marker. We also found that the N-terminal region (aa 3-10) of Z was critical for its myristoylation and VLP production. These findings will contribute to our understanding of LASV assembly and budding. | |||||
書誌情報 |
Journal of General Virology 巻 96, 号 7, p. 1626-1635, 発行日 2015-07-01 |
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出版者 | ||||||
出版者 | Society for General Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00221317 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14652099 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1099/vir.0.000105 | |||||
権利 | ||||||
権利情報 | c 2015 Microbiology Society | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of General Virology, 96(7), pp.1626-1635; 2015 |