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Minor contribution of cytotoxic T lymphocyte antigen 4 and programmed cell death ligand 1 in immune tolerance against mouse thyrotropin receptor in mice
http://hdl.handle.net/10069/36009
http://hdl.handle.net/10069/36009a32b2d3e-a8f4-428c-8d51-9c30c4ba6c18
名前 / ファイル | ライセンス | アクション |
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ISYK770_Yasui.pdf (675.4 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2015-12-07 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Minor contribution of cytotoxic T lymphocyte antigen 4 and programmed cell death ligand 1 in immune tolerance against mouse thyrotropin receptor in mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyrotropin receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CTLA-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PD-L 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Grave's disease | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
安井, 順一
× 安井, 順一 |
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著者別名 | ||||||
姓名 | Yasui, Junichi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have previously shown that wild type (wt) mice exhibit susceptibility to immunization with human (h) thyrotropin receptor (TSHR), but resistance to mouse (m) TSHR, while TSHR knockout (KO) mice are susceptible to mTSHR, indicating the existence of robust immune tolerance against the mTSHR in wt mice. This tolerance may be mediated by either centrally or peripherally. We here explored the contribution of a peripheral arm of immune tolerance against the mTSHR by using antibodies to deplete regulatory T cells (Tregs), to antagonize co-inhibitory molecules and/or to stimulate co-stimulatory molecules. Antagonistic anti-co-inhibitory molecules, cytotoxic T lymphocyte antigen 4 (CTLA4) and programmed cell death 1 ligand 1 (PDL1), induced only low levels of anti-TSHR antibodies without induction of hyperthyroidism in a mouse Graves'model. In this experimental setting, antibody levels were significantly higher in THSR+/- mice than wt mice. However, agonistic anti-co-stimulatory molecules, CD40 and CD137, and Treg-depleting anti-CD25 antibodies showed no effect. All these data suggest that peripheral immune tolerance against the mTSHR may play a minor role, and imply the importance of central tolerance, in immune tolerance against mTSHR in mice. Additional studies on central tolerance to the mTSHR will be necessary for completely delineating the mechanisms for immune tolerance against mTSHR in mice. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第770号 学位授与年月日:平成27年3月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Yasui Junichi, Nakahara Mami, Shimamura Mika, Kurashige Tomomi, Yasui Kazuaki, Abiru Norio, Kawakami Atsushi, Nagayama Yuji | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Acta medica Nagasakiensia, 59(1), pp.13-17; 2014 | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 59, 号 1, p. 13-17, 発行日 2015-03-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
権利 | ||||||
権利情報 | c 2014 Nagasaki University School of Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | マウスTSH受容体に対する免疫寛容におけるCTLA-4とPD-L1の寄与は僅かである。 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/35648 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2015-03-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第770号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2015-03-20) |