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Anticancer Activity of Atractylodes lancea (Thunb.) DC in a Hamster Model and Application of PET-CT for Early Detection and Monitoring Progression of Cholangiocarcinoma
http://hdl.handle.net/10069/36034
http://hdl.handle.net/10069/36034ecffef00-785f-42a1-999c-573b6d9d9e92
名前 / ファイル | ライセンス | アクション |
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APJCP16_6279.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-12-10 | |||||
タイトル | ||||||
タイトル | Anticancer Activity of Atractylodes lancea (Thunb.) DC in a Hamster Model and Application of PET-CT for Early Detection and Monitoring Progression of Cholangiocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anticancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atractylodes lancea (Thunb.) DC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cholangiocarcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PET-CT | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Plengsuriyakarn, Tullayakorn
× Plengsuriyakarn, Tullayakorn× Matsuda, Naoki× Karbwang, Juntra× Vithoon, Viyanant× Kenji, Hirayama× Kesara, Na-Bangchang |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Opisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) is an important cancer in the Great Mekong region, particularly in Thailand. Limitations of treatment options and the lack of an effective diagnostic tool for early detection of CCA are major concerns for the control of this type of cancer. The aim of the study was to investigate anti-CCA activity of the ethanolic extract of Atractylodes lancea (Thunb.) DC., and the applicability of positron emission tomography-computed tomography (PET-CT) as a tool for detection and monitoring the progression of CCA in Opisthorchis viverrini (OV)/dimethylnitrosamine (DMN)-induced CCA hamsters. Male Syrian hamsters were used for toxicity tests and anti-CCA activity evaluation. Development of CCA was induced by initial feeding of 50 metacercariae of OV, followed by drinking water containing 12.5 ppm of DMN in hamsters. The ethanolic extract of A. lancea (Thunb.) DC. was administered orally for 30 days. PET-CT was performed every 4 weeks after initiation of CCA using 18F-fluorodeoxyglucose (18F-FDG). Results from the present study suggest that the ethanolic extract of A. lancea (Thunb.) DC. rhizome exhibited promising anti-CCA activity and safety profile in the OV/DMN-induced hamster model. To successfully apply PET-CT as a tool for early detection of tumor development and progression, modification of radiolabeling approach is required to improve its specificity for CCA cells. | |||||
書誌情報 |
Asian Pacific Journal of Cancer Prevention 巻 16, 号 15, p. 6279-6284, 発行日 2015 |
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出版者 | ||||||
出版者 | Asian Pacific Organization for Cancer Prevention | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15137368 | |||||
権利 | ||||||
権利情報 | c National Cancer Center, Korea. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Asian Pacific Journal of Cancer Prevention, 16(15), pp.6279-6284; 2015 |