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Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice
http://hdl.handle.net/10069/36040
http://hdl.handle.net/10069/36040e40a37e5-1c8d-448d-8604-e2b96517d61d
名前 / ファイル | ライセンス | アクション |
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ExAn64_375.pdf (590.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-12-11 | |||||
タイトル | ||||||
タイトル | Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Helicobacter sp. MIT 01-6451 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Laboratory mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reproductive organ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vertical transmission | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamanaka, Hitoki
× Yamanaka, Hitoki× Nakanishi, Tai× Takagi, Toshikazu× Ohsawa, Makiko× Kubo, Noriaki× Yamamoto, Naoto× Takemoto, Takahira× Ohsawa, Kazutaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Helicobacter sp. MIT 01-6451 has been detected in SPF mice kept in Japan. To characterize strain MIT 01-6451, its infection route during fetal and neonatal life and effects on pregnancy were investigated using immunocompetent and immunodeficient mouse strains (BALB/c, C57BL/6, and SCID). MIT 01-6451 was detected in the uterus, vagina, and mammary glands of 50% of infected SCID mice, whereas these tissues were all negative in immunocompetent mice. No fetal infections with MIT 01-6451 were detected at 16?18 days after pregnancy in any mouse strain. In newborn mice, MIT 01-6451 was detected in intestinal tissue of C57BL/6 and SCID mice at 9?11 days after birth, but not in BALB/c mice. The IgA and IgG titers to MIT 01-6451 in sera of C57BL/6 female mice were significantly lower than those of BALB/c mice. Although no significant differences in the number of newborns per litter were observed between MIT 01-6451-infected and MIT 01-6451-free dams, the birth rate was lower in infected SCID mice than in control SCID mice. The present results indicated that MIT 01-6451 infects newborn mice after birth rather than by vertical transmission to the fetus via the placenta and that MIT 01-6451 infection shows opportunistically negative effects on the birth rate. In addition, the maternal immune response may affect infection of newborn mice with MIT 01-6451 through breast milk. | |||||
書誌情報 |
Experimental Animals 巻 64, 号 4, p. 375-382, 発行日 2015-10-23 |
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出版者 | ||||||
出版者 | 日本実験動物学会 | |||||
出版者別言語 | ||||||
Japanese Association for Laboratory Animal Science | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13411357 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18817122 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1538/expanim.15-0034 | |||||
権利 | ||||||
権利情報 | c2015 Japanese Association for Laboratory Animal Science. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experimental Animals, 64(4), pp.375-382; 2015 |