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Methods: The 349 patients who underwent a minor salivary gland biopsy (MSGB) for suspected SS were retrospectively classified by AECG classification criteria and divided with or without anti-HTLV-I antibody. Results: The HTLV-I data-available 294 patients were investigated. One hundred-seventy patients were classified as SS and 26.5 % were HTLV-I-seropositive. We have included 26 patients with HTLV-I-associated myelopathy (HAM) and 38.5 % were classified as having SS. The prevalences of ANA and anti-SS-A/Ro antibody of HAM + SS were significantly low compared to the HTLV-I asymptomatic carriers (AC) with SS and the HTLV-I-seronegative SS patients, although lacrimal dysfunction tended to be high in HAM + SS and significantly high in AC + SS patients compared with the patients with HTLV-I-seronegative SS. The focus scores of MSGB in the HAM + SS patients were similar to those of the AC + SS patients and the HTLV-I-seronegative patients with SS. 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Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjogren’s syndrome
http://hdl.handle.net/10069/36072
http://hdl.handle.net/10069/360725b244c2f-7a9f-48d6-9611-9837ac1d5cc5
名前 / ファイル | ライセンス | アクション |
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BMCMD16_335.pdf (857.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-12-21 | |||||
タイトル | ||||||
タイトル | Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjogren’s syndrome | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AECG criteria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HTLV-I | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Minor salivary gland biopsy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sjogren's syndrome | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakamura, Hideki
× Nakamura, Hideki× Shimizu, Toshimasa× Takagi, Yukinori× Takahashi, Yoshiko× Horai, Yoshiro× Nakashima, Yoshikazu× Sato, Shuntaro× Shiraishi, Hirokazu× Nakamura, Tatsufumi× Fukuoka, Junya× Nakamura, Takashi× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The aim of the study was to reassess the prevalence and characteristics of human T lymphotropic virus type I (HTLV-I)-associated Sjogren's syndrome (SS) and SS in HTLV-I-associated myelopathy (HAM) based on the American European Consensus Group (AECG) criteria in HTLV-I endemic area, Nagasaki prefecture. Methods: The 349 patients who underwent a minor salivary gland biopsy (MSGB) for suspected SS were retrospectively classified by AECG classification criteria and divided with or without anti-HTLV-I antibody. Results: The HTLV-I data-available 294 patients were investigated. One hundred-seventy patients were classified as SS and 26.5 % were HTLV-I-seropositive. We have included 26 patients with HTLV-I-associated myelopathy (HAM) and 38.5 % were classified as having SS. The prevalences of ANA and anti-SS-A/Ro antibody of HAM + SS were significantly low compared to the HTLV-I asymptomatic carriers (AC) with SS and the HTLV-I-seronegative SS patients, although lacrimal dysfunction tended to be high in HAM + SS and significantly high in AC + SS patients compared with the patients with HTLV-I-seronegative SS. The focus scores of MSGB in the HAM + SS patients were similar to those of the AC + SS patients and the HTLV-I-seronegative patients with SS. Among the MSGB-positive patients, there was a low prevalence of ANA in the HAM + SS patients. Similar results were obtained in case of anti-SS-A/Ro or SS-B/La antibody. Conclusion: In HTLV-I endemic area, high prevalence of anti-HTLV-I antibody among SS as well as the characteristics of HAM + SS and AC + SS was still determined by AECG classification criteria. | |||||
書誌情報 |
BMC Musculoskeletal Disorders 巻 16, p. 335, 発行日 2015-11-04 |
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出版者 | ||||||
出版者 | BioMed Central | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14712474 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s12891-015-0773-1 | |||||
権利 | ||||||
権利情報 | c Nakamura et al. 2015 | |||||
権利 | ||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://?creativecommons.?org/?licenses/?by/?4.?0/?), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://?creativecommons.?org/?publicdomain/?zero/?1.?0/?) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BMC Musculoskeletal Disorders, 16, 335; 2015 |