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Influence of Liver Intoxication by Carbon Tetrachloride or D-Galactosamine on Absorption of Fluorescein Isothiocyanate-Dextran-10 and Other Marker Compounds with Different Molecular Weights from the Rat Liver Surface
http://hdl.handle.net/10069/39664
http://hdl.handle.net/10069/39664ed6fff8f-b815-4aaf-95f7-00ce05e9c42a
名前 / ファイル | ライセンス | アクション |
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BPBul43_319.pdf (658.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-18 | |||||
タイトル | ||||||
タイトル | Influence of Liver Intoxication by Carbon Tetrachloride or D-Galactosamine on Absorption of Fluorescein Isothiocyanate-Dextran-10 and Other Marker Compounds with Different Molecular Weights from the Rat Liver Surface | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | absorption | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver surface | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dextran | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carbon tetrachloride | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | D-galactosamine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyamoto, Hirotaka
× Miyamoto, Hirotaka× Tsuda, Kayoko× Honda, Tominori× Tokunaga, Ayako× Fumoto, Shintaro× Nishida, Koyo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the influence of liver disease on the absorption from the liver surface of fluorescein isothiocyanate (FITC)-dextran 10 (FD-10, MW: 11000) and several marker compounds with different molecular weights. The purpose of this study was to determine the feasibility of liver surface application of macromolecular compounds in the disease state. We used male Wistar rats treated with carbon tetrachloride (CCl4) or D-galactosamine (GAL). FD-10 and other marker compounds were applied to the liver surface using a cylindrical diffusion cell in liver-intoxicated rats. The blood, bile, urine, and the remaining solution in the diffusion cell were collected for assay. FD-10 was absorbed by first-order kinetics from the liver surface in the liver-intoxicated rat models. The calculated rate constant ka values in the normal, CCl4 and GAL groups were 0.000965, 0.00125 and 0.00104 min-1, respectively. Increased absorption of FITC-dextrans in the liverintoxicated rats was observed. In both CCl4 and GAL groups, an inverse relationship was observed between the molecular weight and ka from the rat liver surface of the marker compounds. The limits of the molecular weight absorbed from the liver surface were extrapolated to be 71200, 135000, and 105000 in the normal, CCl4, and GAL groups, respectively. In conclusion, increased absorbability from the rat liver surface indicates that liver surface application for liver targeting of macromolecules in the diseased state is indeed feasible. Therefore, our findings can support further research on liver surface application of drugs under liver disease. | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 43, 号 2, p. 319-324, 発行日 2020-02-01 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
出版者別言語 | ||||||
日本薬学会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b19-00686 | |||||
権利 | ||||||
権利情報 | c 2020 The Pharmaceutical Society of Japan. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & pharmaceutical bulletin, 43(2), pp.319-324; 2020 |