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Relationships Between Clinical Characteristics and Decreased Plakoglobin and Connexin 43 Expressions in Myocardial Biopsies From Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
http://hdl.handle.net/10069/36126
http://hdl.handle.net/10069/3612683260c07-b52c-40f0-b236-d802c80c0b7d
名前 / ファイル | ライセンス | アクション |
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IHJ56_626.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-01-25 | |||||
タイトル | ||||||
タイトル | Relationships Between Clinical Characteristics and Decreased Plakoglobin and Connexin 43 Expressions in Myocardial Biopsies From Patients With Arrhythmogenic Right Ventricular Cardiomyopathy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Arrhythmia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intercalated disc | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pathology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshida, Takeo
× Yoshida, Takeo× Kawano, Hiroaki× Kusumoto, Saburo× Fukae, Satoki× Koga, Seiji× Ikeda, Satoshi× Koide, Yuji× Abe, Kuniko× Hayashi, Tomayoshi× Maemura, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Reduced expressions of plakoglobin and connexin 43 have been reported in the myocardium of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, the relationships between these expression abnormalities and the clinical features of ARVC remain unknown. The expressions of plakoglobin and connexin 43 in myocardial biopsy specimens from 10 patients with confirmed ARVC, and 13 control patients without ARVC (non-ARVC; hypertrophic cardiomyopathy, n = 7; dilated cardiomyopathy, n = 6), were examined by immunostaining to evaluate the relationships between these expressions and the clinical characteristics of ARVC. The ratios of plakoglobin/N-cadherin and of plakoglobin/connexin 43 expressions were significantly lower in the ARVC group than in the control group. Significantly more patients had decreased plakoglobin expression in the ARVC group than in the control group (9/10 versus 7/13; P = 0.0376). Sustained ventricular tachycardia occurred more frequently in patients with ARVC and with decreased expressions of both plakoglobin and connexin 43 than in those with decreased expression of plakoglobin alone (5/5 versus 1/4, P = 0.048). Decreased expressions of both connexin 43 and plakoglobin in the myocardium might be associated with the development of arrhythmia in ARVC. | |||||
書誌情報 |
International Heart Journal 巻 56, 号 6, p. 626-631, 発行日 2015-12-02 |
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出版者 | ||||||
出版者 | インターナショナル・ハート・ジャーナル刊行会 | |||||
出版者別言語 | ||||||
International Heart Journal Association | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13492365 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13493299 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1536/ihj.15-144 | |||||
権利 | ||||||
権利情報 | c 2015 by the International Heart Journal Association | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Heart Journal, 56(6), pp.626-631; 2015 |