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Down-Regulation of Nogo-B Expression as a Newly Identified Feature of Intrahepatic Cholangiocarcinoma
http://hdl.handle.net/10069/36135
http://hdl.handle.net/10069/36135a31648b2-d986-48c8-bfcb-bcab8bb4c399
名前 / ファイル | ライセンス | アクション |
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TJEM238_9.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-01-25 | |||||
タイトル | ||||||
タイトル | Down-Regulation of Nogo-B Expression as a Newly Identified Feature of Intrahepatic Cholangiocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cholangiole proliferation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hepatic resection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intrahepatic cholangiocarcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macroscopic finding | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nogo-B | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nanashima, Atsushi
× Nanashima, Atsushi× Hatachi, Go× Tominaga, Tetsurou× Murakami, Goushi× Takagi, Katsunori× Arai, Junichi× Wada, Hideo× Nagayasu, Takeshi× Sumida, Yorihisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Nogo-B, located in the endoplasmic reticulum, is an isoform belonging to the reticulon protein family, which is expressed specifically in cholangiocytes and non-parenchymal cells in the liver. Nogo-B expression is down-regulated with the progression of liver fibrosis, but its distinct function in liver malignancies has not been fully clarified. We have hypothesized that Nogo-B expression may be altered in intrahepatic cholangiocarcinoma (ICC), a relatively rare type of primary liver cancer with highly malignant behavior. The present study aimed to investigate the relationship between Nogo-B expression, assessed by immunohistochemical staining, and clinicopathological factors and prognosis in 34 ICC patients. Positive expression was observed in 19 (56%) of 34 ICC specimens: 6 patients (18%) with positivity levels of 1+ (positive cells in 10-50% of cancer cells) and 13 patients (38%) with 2+ (positive cells over 50%). Importantly, the remaining 15 patients (44%) were categorized as negative expression (Nogo-B-positive cells, less than 10%). Conversely, the mass-forming type of ICC tended to express Nogo-B with the degree of 2+ positivity, compared to the periductal infiltration type (p = 0.064), and the mass-forming type showed a better 5-year survival rate (66% vs. 5%) after hepatectomy (p < 0.05). However, the degree of positivity was not associated with tumor relapse rate, disease-free and overall survival, although each of the periductal infiltration type, intrahepatic metastasis, larger tumor size, and lower microvessel counts was associated with lower survival rates. We propose that Nogo-B expression is down-regulated in ICC, the implication of which, however, remains to be investigated. | |||||
書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 238, 号 1, p. 9-16, 発行日 2015-12-09 |
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出版者 | ||||||
出版者 | 東北ジャーナル刊行会 | |||||
出版者別言語 | ||||||
Tohoku University Medical Press | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13493329 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.238.9 | |||||
権利 | ||||||
権利情報 | c 2016 Tohoku University Medical Press | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Tohoku Journal of Experimental Medicine, 238(1), pp.9-16; 2016 |