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Although adult T-cell leukemia (ATL) cells are well known to release large amounts of\nsIL-2R,it remains unclear to what extent B-cell lymphoma cells shed sIL-2R in sera. Subtypes of mature B-cell lymphoma, including\nCD25+ hairy leukemic cells, were examined for the characteristics of sIL-2R levels in each subtype. In normal controls, the\nserum sIL-2R mean value was 260u/mL.The median serum sIL-2R value for 64 B-cell lymphoma cases was 506 u/mL;by subtype\nthe median values were as follows: 1157 u/mL for 7 cases of chronic lymphocytic leukemia/hairy cell leukemia (CLL/HCL), 451\nu/mL for 38 cases of diffuse large B-cell lymphoma (DLBCL), and 456 u/mL for 19 cases of follicular Lymphoma (FL). The median\nvalues of serum LDH activity by the above subtypes were 175 IU/mL, 204 IU/mL, and 198 IU/mL, respectively. There was\ndistinct inter-subtype and inter-patient variation of serum sIL-2R.In particular, inter-case variation could be grouped into value for\nthree concentration ranges: less than 300 u/mL, 300-1000 u/mL, and greater than 1000 u/mL. Cases with serum sIL-2R values\nof 1000 u/mL or more tended to have an especially high sIL-2R to LDH ratio, suggesting a close relationship between high sIL-2R\nand CD25-expressing lymphoma cells. With respect to sIL-2R and LDH levels, CLL/HCL, DLBCL, and FL showed similar distributions.\nMoreover, for sIL-2R levels exceeding 1000u/mL, sIL-2R levels were randomly high according to the LDH status. 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Quantitative Features of serum sIL-2R level in Patients with Mature B-Cell Lymphoma? Involvement of LDH
http://hdl.handle.net/10069/36166
http://hdl.handle.net/10069/3616651278582-6331-40d6-8c7e-b8aceb172761
名前 / ファイル | ライセンス | アクション |
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ActMed60_33.pdf (1.9 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-09 | |||||
タイトル | ||||||
タイトル | Quantitative Features of serum sIL-2R level in Patients with Mature B-Cell Lymphoma? Involvement of LDH | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sIL-2R | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bio-marker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RI | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | B-ML | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Matsumoto, Reiko
× Matsumoto, Reiko× Kamihira, Shimeru× Matsubara, Takashi× Yamada, Shouichi× Matsuda, Kazuyuki× Kinoshita, Kazuhisa× Takahashi, Youichi× Kanematsu, Takashi× Nakashima, Kazuhisa× De, Kerckhove Charles |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Serum Lactate Dehydrogenase (LDH) activity and soluble IL-2 Receptor-alpha (sIL-2R) levels are monitored as a marker of disease activity in patients with lymphoma. Although adult T-cell leukemia (ATL) cells are well known to release large amounts of sIL-2R,it remains unclear to what extent B-cell lymphoma cells shed sIL-2R in sera. Subtypes of mature B-cell lymphoma, including CD25+ hairy leukemic cells, were examined for the characteristics of sIL-2R levels in each subtype. In normal controls, the serum sIL-2R mean value was 260u/mL.The median serum sIL-2R value for 64 B-cell lymphoma cases was 506 u/mL;by subtype the median values were as follows: 1157 u/mL for 7 cases of chronic lymphocytic leukemia/hairy cell leukemia (CLL/HCL), 451 u/mL for 38 cases of diffuse large B-cell lymphoma (DLBCL), and 456 u/mL for 19 cases of follicular Lymphoma (FL). The median values of serum LDH activity by the above subtypes were 175 IU/mL, 204 IU/mL, and 198 IU/mL, respectively. There was distinct inter-subtype and inter-patient variation of serum sIL-2R.In particular, inter-case variation could be grouped into value for three concentration ranges: less than 300 u/mL, 300-1000 u/mL, and greater than 1000 u/mL. Cases with serum sIL-2R values of 1000 u/mL or more tended to have an especially high sIL-2R to LDH ratio, suggesting a close relationship between high sIL-2R and CD25-expressing lymphoma cells. With respect to sIL-2R and LDH levels, CLL/HCL, DLBCL, and FL showed similar distributions. Moreover, for sIL-2R levels exceeding 1000u/mL, sIL-2R levels were randomly high according to the LDH status. Conclusively, the combination of serum sIL-2R level and LDH activity can provide a better understanding of characteristics of subtypes of mature B-Cell Lymphoma and can be used as a reliable surrogate marker for evaluating numerical and biological data. |
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書誌情報 |
Acta medica Nagasakiensia 巻 60, 号 2, p. 33-37, 発行日 2016-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
1 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 60(2), pp.33-37; 2016 |