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We examined the urinary iodine (UI) concentrations of pregnant women in Ukraine, where the iodine status is showing improvement among the general population. Methods: We enrolled 148 pregnant women\u003c16 weeks pregnant and 80 healthy women as a control group living in Zhitomir, Ukraine. UI concentration, thyroid-stimulating hormone (TSH), antithyroglobulin antibodies (TGAb), and antithyroid peroxidase antibodies (TPOAb) were measured. Results: The median UI concentrations were significantly lower in pregnant women than in control women [13.0 (ND - 51.0) μg/L vs. 62.0 (35.3 - 108.5) μg/L, p\u003c0.001]. TSH concentrations were significantly lower in pregnant women than in control women [1.7 (1.2 - 2.7) IU/L vs. 2.2 (1.4 - 3.1) IU/L, p = 0.011], but this difference disappeared when adjusted for age (2.1 ± 0.1 IU/L vs. 2.4 ± 0.2 IU/L, p = 0.097). The frequency of TSH over 6.2 IU/L and the frequency of positive TGAb and/or TPOAb were not statistically different between groups (p = 0.70 and p = 0.48, respectively). The UI concentrations of 142 pregnant women (95.9 % ) were\u003c150 μg/L indicating insufficient iodine intake. Conclusions: The UI concentration of pregnant women in Ukraine revealed severe iodine deficiency. Regular monitoring and appropriate nutrition education are essential because iodine deficiency can be easily prevented by adequate iodine intake. The risk of iodine deprivation during pregnancy needs to be assessed locally over time because it may occur in areas that are not globally recognized as being iodine-deficient.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Clinical Chemistry and Laboratory Medicine, 51(4), pp.811-816; 2013", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Walter de Gruyter GmbH \u0026 Co. 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Urinary iodine concentrations of pregnant women in Ukraine
http://hdl.handle.net/10069/34080
http://hdl.handle.net/10069/340807be1b05c-4bf9-48a8-86d7-306a89093ec3
名前 / ファイル | ライセンス | アクション |
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CCLM51_811.pdf (192.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-05-01 | |||||
タイトル | ||||||
タイトル | Urinary iodine concentrations of pregnant women in Ukraine | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Iodine deficiency | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pregnancy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ukraine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Urinary iodine concentration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sekitani, Yui
× Sekitani, Yui× Hayashida, Naomi× Takahashi, Jumpei× Kozlovsky, Alexander A.× Rudnitskiy, Stanislav× Petrova, Anjelika× Gutevych, Oleksandr K.× Chorniy, Sergiy A.× Yamashita, Shunichi× Takamura, Noboru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Iodine requirements increase during pregnancy and previous studies have reported the inadequate iodine status of pregnant women in areas that have achieved iodine sufficiency in the general population. We examined the urinary iodine (UI) concentrations of pregnant women in Ukraine, where the iodine status is showing improvement among the general population. Methods: We enrolled 148 pregnant women<16 weeks pregnant and 80 healthy women as a control group living in Zhitomir, Ukraine. UI concentration, thyroid-stimulating hormone (TSH), antithyroglobulin antibodies (TGAb), and antithyroid peroxidase antibodies (TPOAb) were measured. Results: The median UI concentrations were significantly lower in pregnant women than in control women [13.0 (ND - 51.0) μg/L vs. 62.0 (35.3 - 108.5) μg/L, p<0.001]. TSH concentrations were significantly lower in pregnant women than in control women [1.7 (1.2 - 2.7) IU/L vs. 2.2 (1.4 - 3.1) IU/L, p = 0.011], but this difference disappeared when adjusted for age (2.1 ± 0.1 IU/L vs. 2.4 ± 0.2 IU/L, p = 0.097). The frequency of TSH over 6.2 IU/L and the frequency of positive TGAb and/or TPOAb were not statistically different between groups (p = 0.70 and p = 0.48, respectively). The UI concentrations of 142 pregnant women (95.9 % ) were<150 μg/L indicating insufficient iodine intake. Conclusions: The UI concentration of pregnant women in Ukraine revealed severe iodine deficiency. Regular monitoring and appropriate nutrition education are essential because iodine deficiency can be easily prevented by adequate iodine intake. The risk of iodine deprivation during pregnancy needs to be assessed locally over time because it may occur in areas that are not globally recognized as being iodine-deficient. | |||||
書誌情報 |
Clinical Chemistry and Laboratory Medicine 巻 51, 号 4, p. 811-816, 発行日 2013-04 |
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出版者 | ||||||
出版者 | Walter de Gruyter GmbH & Co. KG | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14346621 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14374331 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1515/cclm-2012-0397 | |||||
権利 | ||||||
権利情報 | c 2013 by Walter de Gruyter GmbH | |||||
権利 | ||||||
権利情報 | The final publication is available at www.degruyter.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clinical Chemistry and Laboratory Medicine, 51(4), pp.811-816; 2013 |