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High expression of trimethylated histone H3 at lysine 27 predicts better prognosis in non-small cell lung cancer
http://hdl.handle.net/10069/34168
http://hdl.handle.net/10069/341687088d912-94b8-4246-90e3-5c63bd1d7a9c
名前 / ファイル | ライセンス | アクション |
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IJO43_1467.pdf (2.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-01 | |||||
タイトル | ||||||
タイトル | High expression of trimethylated histone H3 at lysine 27 predicts better prognosis in non-small cell lung cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA methylation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enhancer of zeste homolog 2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epigenetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-small cell lung cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Trimethylated histone H3 at lysine 27 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chen, Xiaohui
× Chen, Xiaohui× Song, Ning× Matsumoto, Keitaro× Nanashima, Atsushi× Nagayasu, Takeshi× Hayashi, Tomayoshi× Ying, Mingang× Endo, Daisuke× Wu, Zhiren× Koji, Takehiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epigenetic parameters such as DNA methylation and histone modifications play pivotal roles in carcinogenesis. Global histone modification patterns have been implicated as possible predictors of cancer recurrence and prognoses in a great variety of tumor entities. Our study was designed to evaluate the association among trimethylated histone H3 at lysine 27 (H3K27me3), clinicopathological variables and outcome in early-stage non-small cell lung cancer (NSCLC). The expression of H3K27me3 and its methyltransferase, enhancer of zeste homolog 2 (EZH2) together with proliferating cell nuclear antigen (PCNA) were evaluated by immunohistochemistry in normal lung tissue (n=5) and resected NSCLC patients (n=42). In addition, the specificity of antibody for H3K27me3 was tested by western blot analysis. The optimal cut-off point of H3K27me3 expression for prognosis was determined by the X-tile program. The prognostic significance was determined by means of Kaplan-Meier survival estimates and log-rank tests. As a result, enhanced trimethylation of H3K27me3 was correlated with longer overall survival (OS) and better prognosis (P<0.05). Moreover, both univariate and multivariate analyses indicated that H3K27me3 level was a significant and independent predictor of better survival (hazard ratio, 0.187; 95% confidence interval, 0.066-0.531, P=0.002). Furthermore, H3K27me3 expression was positively correlated with DNA methylation level at CCGG sites while reversely related to EZH2 expression (P<0.05). In conclusion, H3K27me3 level defines unrecognized subgroups of NSCLC patients with distinct epigenetic phenotype and clinical outcome, and can probably be used as a novel predictor for better prognosis in NSCLC patients. | |||||
書誌情報 |
International Journal of Oncology 巻 43, 号 5, p. 1467-1480, 発行日 2013-11 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10196439 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17912423 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ijo.2013.2062 | |||||
権利 | ||||||
権利情報 | c Spandidos Publications 2013. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Oncology, 43(5), pp.1467-1480; 2013 |