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Dengue virus serotype-4 during the 2015-2017 epidemic: emergence of a novel genotype IIa of DENV-4 in the Philippines
http://hdl.handle.net/10069/39681
http://hdl.handle.net/10069/396814bc1f67c-07e4-4ec6-88ff-cf66cb2b7273
名前 / ファイル | ライセンス | アクション |
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ISYK1187_DeVeraLuz.pdf (2.0 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-02-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Dengue virus serotype-4 during the 2015-2017 epidemic: emergence of a novel genotype IIa of DENV-4 in the Philippines | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dengue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | emergence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Philippines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genotype | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
DE, VERA LUZ MARK ANTHONY
× DE, VERA LUZ MARK ANTHONY |
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著者別名 | ||||||
姓名 | デ ベラ ルズ, マーク アンソニー | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dengue remains a major public health problem in the Philippines. In this study, we determined the circulating dengue serotypes in the Philippines during the 2015?2017 outbreaks using a total of 678 serum samples from 537 individual dengue patients. Following an increase in the number of DENV-4 patients in recent years, we conducted a comprehensive molecular and epidemiology analysis on the DENV-4 strains isolated recently in the Philippines. Two genotypes of DENV-4 have been isolated in the Philippines since 1956: GI and GIIa. The GIIa DENV strains that were isolated in the present study were closely related to a distinct group of GIIa strains that were isolated from the Philippines in 2004. A majority of the isolates of this sub-group have been identified in the Philippines, suggesting that this lineage may have been introduced in the Philippines, and evolved to form the distinct sub-group within GIIa strains. The increase in DENV-4 activity also coincided with the appearance of the GIIa subgroup and the phasing-out of the GI lineage in the Philippines. Overall, our study demonstrates a shift in DENV-4 genotype and epidemic dynamics in a hyperendemic region, suggesting the importance of DENV genetic evolution in establishing and sustaining transmission. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1187号 学位授与年月日:令和元年9月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Mark Anthony de Vera Luz, Takeshi Nabeshima, Meng Ling Moi, Maria Terrese Alonzo Dimamay, Lady-Anne Suarez Pangilinan, Mark Pierre Sijo Dimamay, Ronald Roll Matias, Cynthia Abad Mapua, Corazon Cerilla Buerano, Ferdinand de Guzman, Edith Sangalang Tria, Filipinas Florendo Natividad, Maria Luisa de Guzman Daroy, Taichiro Takemura, Futoshi Hasebe, Kouichi Morita | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Japanese Journal of Infectious Diseases, 72(6), pp.413-419; 2019 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出版時論題変更 | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 72, 号 6, p. 413-419, 発行日 2019-09-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18842836 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7883/yoken.JJID.2019.208 | |||||
権利 | ||||||
権利情報 | c 2019, National Institute of Health. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | フィリピンにおけるデング4型ウイルスの疫学調査(2015年~2017年):新遺伝子型IIaの出現 | |||||
出版者 | ||||||
出版者 | National Institute of Infectious Diseases | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/39486 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-09-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1187号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2019-09-20) |