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Overexpression of Leptin Reduces the Ratio of Glycolytic to Oxidative Enzymatic Activities without Changing Muscle Fiber Types in Mouse Skeletal Muscle
http://hdl.handle.net/10069/34189
http://hdl.handle.net/10069/34189f75f40ab-25df-4040-b71f-cb701084ccae
名前 / ファイル | ライセンス | アクション |
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BPBul37_169.pdf (485.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-03-11 | |||||
タイトル | ||||||
タイトル | Overexpression of Leptin Reduces the Ratio of Glycolytic to Oxidative Enzymatic Activities without Changing Muscle Fiber Types in Mouse Skeletal Muscle | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Citrate synthase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lactate dehydrogenase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Leptin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myosin heavy chain | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Masuda, Shinya
× Masuda, Shinya× Tanaka, Tomohiro× Masuzaki, Hiroaki× Nakao, Kazuwa× Taguchi, Sadayoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Increased spontaneous locomotive activity and oxygen consumption have been reported in transgenic mice overexpressing leptin in the liver. In the present study, we examined whether the overexpression of leptin altered glycolytic and oxidative metabolic enzymatic activities as well as the composition of myosin heavy chain (MHC) isoforms in skeletal muscle. Enzymatic activities of lactate dehydrogenase (LDH) and citrate synthase (CS) were quantified in gastrocnemius muscle (GAS) and the red portion of tibialis anterior muscle (TA) from leptin transgenic (Tg) mice and non-Tg mice. The composition of MHC isoforms was measured in soleus muscle (SOL) and extensor digitorum longus muscle (EDL) from the two groups. In red TA, LDH-to-CS ratio was significantly lower in Tg than in non-Tg (p=0.014), whereas no significant change was observed in GAS. The composition of MHC isoforms was not significantly different in SOL or EDL between Tg and non-Tg groups. Our data indicate that chronic overexpression of leptin reduces the ratio of glycolytic to oxidative capacity without changing muscle fiber types particularly in red muscles. This metabolic change may contribute to the increased spontaneous locomotive activity and oxygen consumption in Tg mice reported previously. | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 37, 号 1, p. 169-173, 発行日 2014-01-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b13-00557 | |||||
権利 | ||||||
権利情報 | c 2014 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological and Pharmaceutical Bulletin, 37(1), pp.169-173; 2014 |