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Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner
http://hdl.handle.net/10069/34299
http://hdl.handle.net/10069/342996238eecb-0925-4567-ad60-97808697547f
名前 / ファイル | ライセンス | アクション |
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MSM20_297.pdf (497.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-04-23 | |||||
タイトル | ||||||
タイトル | Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Asthma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Leukotriene antagonists | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphoid tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pranlukast | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawano, Tetsuya
× Kawano, Tetsuya× Matsuse, Hiroto× Tsuchida, Tomoko× Fukahori, Susumu× Fukushima, Chizu× Nishino, Tomoya× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Cysteinyl leukotrienes (cys-LTs) are very important factors in the pathophysiology of bronchial asthma. Cys-LT receptor antagonists (LTRAs) decrease allergic airway inflammation. The aim of the present study was to determine the differential effects of LTRAs and corticosteroids on allergic airway inflammation and allergen-specific cytokine production from lymphoid tissues using a murine model of asthma. Material/Methods: Four groups of female BALB/c mice [control (Cont); Dermatophagoides farinae allergen-sensitized (AS); pranlukast (Prl), an LTRA-treated AS; and dexamethasone (Dex)-treated AS] were examined. Lung pathology and cytokine production by prepared mononuclear cells isolated from mediastinal lymph nodes (MLNs) and spleen were compared among these groups. Results: AS mice exhibited allergic airway inflammation and significant increases in allergen-specific Th1 and Th2 cytokines in MLNs and spleen. Prl-treated mice showed significant attenuation of allergic airway inflammation concomitant with reduction of Th2 cytokines and IFN-g in MLNs but not in spleen. In contrast, Dex significantly decreased Th1 and Th2 cytokines in MLNs and also decreased them (except IL-13 and IL-2) in spleen. Conclusions: The inflammatory effects of cys-LTs could differ in lymphoid organs. LTRAs potentially regulate allergic airway inflammation in an organ- and cytokine-specific manner, while systemic corticosteroid shows nonspecific effects. | |||||
書誌情報 |
Medical Science Monitor 巻 20, p. 297-302, 発行日 2014-02-22 |
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出版者 | ||||||
出版者 | International Scientific Literature Inc. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16433750 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.12659/MSM.889865 | |||||
権利 | ||||||
権利情報 | c Med Sci Monit, 2014. | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medical Science Monitor, 20, pp.297-302; 2014 |