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Anti-influenza A virus activity of a new dihydrochalcone diglycoside isolated from the Egyptian seagrass Thalassodendron ciliatum (Forsk.) den Hartog
http://hdl.handle.net/10069/34364
http://hdl.handle.net/10069/34364b4696894-6a30-4648-aadb-27282d6d67af
名前 / ファイル | ライセンス | アクション |
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NPR28_377.pdf (3.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-03-20 | |||||
タイトル | ||||||
タイトル | Anti-influenza A virus activity of a new dihydrochalcone diglycoside isolated from the Egyptian seagrass Thalassodendron ciliatum (Forsk.) den Hartog | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiviral | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cymodoceaceae | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dihydrochalcones | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phenolics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | structure-activity relationship studies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thalassodendron ciliatum (Forsk.) den Hartog | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mohammed, Magdy M.D.
× Mohammed, Magdy M.D.× Hamdy, Abdel-Hamid A.× El-Fiky, Nabaweye M.× Mettwally, Walaa S.A.× El-Beih, Ahmed A.× Kobayashi, Nobuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | One new dihydrochalcone diglycoside has been isolated from the EtOAc fraction of the Egyptian seagrass Thalassodendrin ciliatum (Forsk.) den Hartog, and was identified as 6′-O-rhamnosyl-(1? → 6″)-glucopyranosyl asebogenin for which a trivial name Thalassodendrone was established. Furthermore, five known phenolics were isolated and identified as asebotin, quercetin 3,7-diglucoside, protocatechuic acid, ferulic acid and p-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and high-resolution-mass spectrometer. High-resolution electrospray ionization mass spectra (HR-ESI-MS) were obtained using a JEOL JMS-T100TD spectrometer (JEOL Ltd., Tokyo, Japan). The anti-influenza A virus activity of the isolated new compound and asebotin was evaluated, and the obtained results revealed that the inhibition dose concentration of asebotin was more than that of Thalassodendrone with IC 50 = 2.00 and 1.96 μg/mL, respectively, and with cytotoxic concentration (CC50) of 3.36 and 3.14 μg/mL, respectively. | |||||
書誌情報 |
Natural Product Research 巻 28, 号 6, p. 377-382, 発行日 2014-03-19 |
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出版者 | ||||||
出版者 | Taylor and Francis Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14786419 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14786427 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/14786419.2013.869694 | |||||
権利 | ||||||
権利情報 | c 2014 Taylor & Francis. | |||||
権利 | ||||||
権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Natural Product Research on 19 March 2014, available online at: http://www.tandfonline.com/10.1080/14786419.2013.869694 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Natural Product Research, 28(6), pp.377-382; 2014 |