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Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein
http://hdl.handle.net/10069/34389
http://hdl.handle.net/10069/34389f1f3172c-9721-407f-ad63-51e5f86609fe
名前 / ファイル | ライセンス | アクション |
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SciRep4_4504.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-05-16 | |||||
タイトル | ||||||
タイトル | Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Homma, Takujiro
× Homma, Takujiro× Ishibashi, Daisuke× Nakagaki, Takehiro× Satoh, Katsuya× Sano, Kazunori× Atarashi, Ryuichiro× Nishida, Noriyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Prion diseases are neurodegenerative disorders characterized by the aggregation of abnormally folded prion protein (PrP Sc). In this study, we focused on the mechanism of clearance of PrP Sc, which remains unclear. p62 is a cytosolic protein known to mediate both the formation and degradation of aggregates of abnormal proteins. The levels of p62 protein increased in prion-infected brains and persistently infected cell cultures. Upon proteasome inhibition, p62 co-localized with PrP Sc, forming a large aggregate in the perinuclear region, hereafter referred to as PrP Sc -aggresome. These aggregates were surrounded with autophagosome marker LC3 and lysosomes in prion-infected cells. Moreover, transient expression of the phosphomimic form of p62, which has enhanced ubiquitin-binding activity, reduced the amount of PrP Sc in prion-infected cells, indicating that the activation of p62 could accelerate the clearance of PrP Sc. Our findings would thus suggest that p62 could be a target for the therapeutic control of prion diseases. | |||||
書誌情報 |
Scientific Reports 巻 4, p. 4504, 発行日 2014-03-28 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20452322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/srep04504 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/34866 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scientific Reports, 4, 4504; 2014 |