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Bisphenol A Does Not Affect Memory Performance in Adult Male Rats
http://hdl.handle.net/10069/34394
http://hdl.handle.net/10069/34394a872fd53-ea17-4c06-a981-d0c9816f43cc
名前 / ファイル | ライセンス | アクション |
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CMN34_333.pdf (514.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-05-01 | |||||
タイトル | ||||||
タイトル | Bisphenol A Does Not Affect Memory Performance in Adult Male Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bisphenol A | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endocrine disruptors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hippocampus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Memory | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oral administration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kuwahara, Rika
× Kuwahara, Rika× Kawaguchi, Shinichiro× Kohara, Yumi× Jojima, Takeshi× Yamashita, Kimihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bisphenol A (BPA) is an estrogenic endocrine disruptor used for producing polycarbonate plastics and epoxy resins. This study investigated the effects of oral BPA administration on memory performance, general activity, and emotionality in adult male Sprague Dawley rats using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) used to assess spatial memory performance. In addition, in order to confirm the effects of BPA on spatial memory performance, we examined whether intrahippocampal injection of BPA affects spatial memory consolidation. In the MAZE test, although oral BPA administration at 10 mg/kg significantly altered the number of entries into the incorrect area compared to those of vehicle-treated rats, male rats given BPA through either oral administration or intrahippocampal injection failed to show significant differences in latencies to reach the reward. Also, oral BPA administration did not affect fear-motivated memory performance in the step-through passive avoidance test. Oral BPA administration at 0.05 mg/kg, the lowest dose used in this study, was correlated with a decrease in locomotor activity in the open-field test, whereas oral administration at 10 mg/kg, the highest dose used in this study, was correlated with a light anxiolytic effect in the elevated plus-maze test. The present study suggests that BPA in adulthood has little effect on spatial memory performance in male rats. | |||||
書誌情報 |
Cellular and Molecular Neurobiology 巻 34, 号 3, p. 333-342, 発行日 2014-04 |
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出版者 | ||||||
出版者 | Springer New York | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02724340 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15736830 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10571-013-0017-6 | |||||
権利 | ||||||
権利情報 | c 2013 Springer Science+Business Media. | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cellular and Molecular Neurobiology, 34(3), pp.333-342; 2014 |