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Plasma Pentraxin 3 is a More Potent Predictor of Endothelial Dysfunction than High-Sensitive C-Reactive Protein
http://hdl.handle.net/10069/34767
http://hdl.handle.net/10069/3476798b5d5ad-01cd-4679-98c9-6ee688a76c50
名前 / ファイル | ライセンス | アクション |
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IHJ55_160.pdf (592.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-10-08 | |||||
タイトル | ||||||
タイトル | Plasma Pentraxin 3 is a More Potent Predictor of Endothelial Dysfunction than High-Sensitive C-Reactive Protein | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Coronary artery disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Flow mediated dilation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inflammation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yasunaga, Tomohiko
× Yasunaga, Tomohiko× Ikeda, Satoshi× Koga, Seiji× Nakata, Tomoo× Yoshida, Takeo× Masuda, Nobuhito× Kohno, Shigeru× Maemura, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An infl ammatory response is a key event for endothelial dysfunction. Pentraxin 3 (PTX3) is an infl ammatory protein produced at infl ammation sites such as leukocytes and vascular endothelial cells. Here, we compared the relationships between endothelial function assessed by flow-mediated dilation (FMD), and the levels of plasma PTX3 and highsensitive C-reactive protein (hsCRP), another infl ammatory protein of the pentraxin family. Levels of FMD, PTX3 and hsCRP were measured twice within 6 to 8 months and retrospectively analyzed in 36 patients with coronary artery disease. We examined the associations between the values of FMD and the levels of PTX3 and hsCRP at the fi rst measurement, and between the change ratios (second value/fi rst value) of these parameters. Univariate linear regression analysis showed significantly negative correlations between FMD values and PTX3 and hsCRP levels at the fi rst measurement, and significant associations with taking statins or calcium antagonists. Multivariate linear stepwise regression analysis identifi ed PTX3 levels and taking statins and calcium antagonists as independent factors for endothelial function. The change ratio of FMD correlated more closely with that of PTX3 than of hsCRP (r =-0.446, P = 0.006 versus r =-0.330, P = 0.050). Significantly more patients with decreased FMD values had increased levels of PTX3 than those of hsCRP at the second measurement compared with the fi rst measurement. Furthermore, the ratio of patients with increased PTX3, but not increased hsCRP, was significantly reduced among those with increased, rather than decreased, FMD values. Endothelial dysfunction might be more accurately predicted by plasma PTX3 levels than by serum hsCRP levels. | |||||
書誌情報 |
International Heart Journal 巻 55, 号 2, p. 160-164, 発行日 2014-03-28 |
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出版者 | ||||||
出版者 | インターナショナル・ハート・ジャーナル刊行会 | |||||
出版者別言語 | ||||||
International Heart Journal Association | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13492365 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13493299 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1536/ihj.13-253 | |||||
権利 | ||||||
権利情報 | c 2014 by the International Heart Journal Association | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Heart Journal, 55(2), pp.160-164; 2014 |