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Neuronal Activity in the Subthalamic Cerebrovasodilator Area under Partial-Gravity Conditions in Rats
http://hdl.handle.net/10069/34407
http://hdl.handle.net/10069/3440779f62751-bee0-4cf6-b664-c9f4c3967a45
名前 / ファイル | ライセンス | アクション |
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Life4_107.pdf (578.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-05-27 | |||||
タイトル | ||||||
タイトル | Neuronal Activity in the Subthalamic Cerebrovasodilator Area under Partial-Gravity Conditions in Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cerebral blood flow | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Electrophysiology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gravity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intracranial EEG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parabolic flight | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Partial gravity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Subthalamic cerebrovasodilator area | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Threshold | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zeredo, Jorge L.
× Zeredo, Jorge L.× Toda, Kazuo× Kumei, Yasuhiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The reduced-gravity environment in space is known to cause an upward shift in body fluids and thus require cardiovascular adaptations in astronauts. In this study, we recorded in rats the neuronal activity in the subthalamic cerebrovasodilator area (SVA), a key area that controls cerebral blood flow (CBF), in response to partial gravity. -Partial gravity{norm of matrix} is the term that defines the reduced-gravity levels between 1 g (the unit gravity acceleration on Earth) and 0 g (complete weightlessness in space). Neuronal activity was recorded telemetrically through chronically implanted microelectrodes in freely moving rats. Graded levels of partial gravity from 0.4 g to 0.01 g were generated by customized parabolic-flight maneuvers. Electrophysiological signals in each partial-gravity phase were compared to those of the preceding 1 g level-flight. As a result, SVA neuronal activity was significantly inhibited by the partial-gravity levels of 0.15 g and lower, but not by 0.2 g and higher. Gravity levels between 0.2-0.15 g could represent a critical threshold for the inhibition of neurons in the rat SVA. The lunar gravity (0.16 g) might thus trigger neurogenic mechanisms of CBF control. This is the first study to examine brain electrophysiology with partial gravity as an experimental parameter. | |||||
書誌情報 |
Life 巻 4, 号 1, p. 107-116, 発行日 2014-03-04 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20751729 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/life4010107 | |||||
権利 | ||||||
権利情報 | c 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Life, 4(1), pp.107-116; 2014 |