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Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-α-Induced Permeability In Vitro
http://hdl.handle.net/10069/34408
http://hdl.handle.net/10069/34408aeb40ba5-d2b4-4bb2-bef3-0a3d9c8e7ec4
名前 / ファイル | ライセンス | アクション |
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JID67_86.pdf (323.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-05-27 | |||||
タイトル | ||||||
タイトル | Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-α-Induced Permeability In Vitro | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Raekiansyah, Muhareva
× Raekiansyah, Muhareva× Espada-Murao, Lyre Anni× Okamoto, Kenta× Kubo, Toru× Morita, Kouichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The mechanisms of endothelial barrier dysfunction in dengue disease remain poorly understood. Endothelial cell (EC) death due to virus infection or in combination with an infection-induced cytokine storm is deemed as one of the major causes of plasma leakage. Using an in vitro model of human endothelia and several dengue virus (DENV) strains (including a clinical isolate), the direct consequence of infection on endothelial permeability was investigated throughout the course of the infection. All employed DENV-2 strains were able to infect and replicate in ECs. Rather than increase endothelial permeability, DENV infection alone enhanced cell barrier integrity up to 7 days postinfection. Improved cell barrier function was mediated by type I interferon activation at the early phase of infection and by the survival advantage of the infected cells at the late phase of infection. Consistent with this phenomenon, DENV infection did not augment tumor necrosis factor-α-induced permeability. Our results prove that DENV infection does not directly account for vascular permeability; DENV neither induces hyperpermeability nor exacerbates the permeabilizing effect of cytokines. The contributory role of other factors on plasma leakage during dengue disease warrants further investigation. | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 67, 号 2, p. 86-94, 発行日 2014-03-20 |
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出版者 | ||||||
出版者 | 国立感染症研究所 | |||||
出版者別言語 | ||||||
National Institute of Infectious Diseases | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7883/yoken.67.86 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Journal of Infectious Diseases, 67(2), pp.86-94; 2014 |