WEKO3
アイテム
{"_buckets": {"deposit": "18416e1c-31bb-4f6f-a9b6-7da7dc606f46"}, "_deposit": {"created_by": 2, "id": "5349", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "5349"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00005349", "sets": ["30"]}, "author_link": ["22576", "22587", "22584", "22585", "22575", "22583", "22586", "22573", "22588", "22571", "22581", "22569", "22572", "22574", "22580", "22579", "22578", "22589", "22582", "22577", "22570", "22568"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03-20", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "915", "bibliographicPageStart": "904", "bibliographicVolumeNumber": "53", "bibliographic_titles": [{"bibliographic_title": "Molecular Cell"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human cells. Invitro evidence indicated that Largen preferentially stimulates the translation of specific subsetsof mRNAs, including those encoding proteins affecting mitochondrial functions. The involvement of Largen in mitochondrial respiration was consistentwith the increased mitochondrial mass and greater ATP production in Largen-overexpressing cells. Furthermore, Largen overexpression led to increased cell size invivo, as revealed by analyses of conditional Largen transgenic mice. Our results establish Largen as an important link between mRNA translation, mitochondrial functions, and the control of mammalian cell size.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Molecular Cell, 53(6), pp.904-915; 2014", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Cell Press"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.molcel.2014.02.028", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2014 Elsevier Inc. All rights reserved."}, {"subitem_rights": "NOTICE: this is the author’s version of a work that was accepted for publication in Molecular Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular Cell, 53, 6, (2014)"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "10972765", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamamoto, Kazuo"}], "nameIdentifiers": [{"nameIdentifier": "22568", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gandin, Valentina"}], "nameIdentifiers": [{"nameIdentifier": "22569", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Masato"}], "nameIdentifiers": [{"nameIdentifier": "22570", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "McCracken, Susan"}], "nameIdentifiers": [{"nameIdentifier": "22571", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li, Wanda"}], "nameIdentifiers": [{"nameIdentifier": "22572", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Silvester, Jennifer Liepa"}], "nameIdentifiers": [{"nameIdentifier": "22573", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Elia, Andrew J."}], "nameIdentifiers": [{"nameIdentifier": "22574", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, Feng"}], "nameIdentifiers": [{"nameIdentifier": "22575", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakutani, Yosuke"}], "nameIdentifiers": [{"nameIdentifier": "22576", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Alexandrova, Roumiana"}], "nameIdentifiers": [{"nameIdentifier": "22577", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oo, Yathor D"}], "nameIdentifiers": [{"nameIdentifier": "22578", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mullen, Peter J."}], "nameIdentifiers": [{"nameIdentifier": "22579", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "22580", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Itsumi, Momoe"}], "nameIdentifiers": [{"nameIdentifier": "22581", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lapin, Valentina"}], "nameIdentifiers": [{"nameIdentifier": "22582", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haight, Jillian"}], "nameIdentifiers": [{"nameIdentifier": "22583", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakeham, Andrew"}], "nameIdentifiers": [{"nameIdentifier": "22584", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shahinian, Arda"}], "nameIdentifiers": [{"nameIdentifier": "22585", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikura, Mitsuhiko"}], "nameIdentifiers": [{"nameIdentifier": "22586", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Topisirovic, Ivan"}], "nameIdentifiers": [{"nameIdentifier": "22587", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sonenberg, Nahum"}], "nameIdentifiers": [{"nameIdentifier": "22588", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mak, Tak W."}], "nameIdentifiers": [{"nameIdentifier": "22589", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Supple.pdf", "filesize": [{"value": "7.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 7800000.0, "url": {"label": "Supple.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/5349/files/Supple.pdf"}, "version_id": "b881fa7a-1e0f-441d-9523-8bdf4b4fb31b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "MolCel53_904.pdf", "filesize": [{"value": "20.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 20200000.0, "url": {"label": "MolCel53_904.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/5349/files/MolCel53_904.pdf"}, "version_id": "fce62ff1-3732-4838-9e10-96ae13c2af35"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Largen: A Molecular Regulator of Mammalian Cell Size Control", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Largen: A Molecular Regulator of Mammalian Cell Size Control"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/34413", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-05-30"}, "publish_date": "2014-05-30", "publish_status": "0", "recid": "5349", "relation": {}, "relation_version_is_last": true, "title": ["Largen: A Molecular Regulator of Mammalian Cell Size Control"], "weko_shared_id": 2}
Largen: A Molecular Regulator of Mammalian Cell Size Control
http://hdl.handle.net/10069/34413
http://hdl.handle.net/10069/344130d1c3379-e2e4-4526-9c3c-0f7e7e9c933b
名前 / ファイル | ライセンス | アクション |
---|---|---|
Supple.pdf (7.8 MB)
|
|
|
MolCel53_904.pdf (20.2 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-05-30 | |||||
タイトル | ||||||
タイトル | Largen: A Molecular Regulator of Mammalian Cell Size Control | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamamoto, Kazuo
× Yamamoto, Kazuo× Gandin, Valentina× Sasaki, Masato× McCracken, Susan× Li, Wanda× Silvester, Jennifer Liepa× Elia, Andrew J.× Wang, Feng× Wakutani, Yosuke× Alexandrova, Roumiana× Oo, Yathor D× Mullen, Peter J.× Inoue, Satoshi× Itsumi, Momoe× Lapin, Valentina× Haight, Jillian× Wakeham, Andrew× Shahinian, Arda× Ikura, Mitsuhiko× Topisirovic, Ivan× Sonenberg, Nahum× Mak, Tak W. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human cells. Invitro evidence indicated that Largen preferentially stimulates the translation of specific subsetsof mRNAs, including those encoding proteins affecting mitochondrial functions. The involvement of Largen in mitochondrial respiration was consistentwith the increased mitochondrial mass and greater ATP production in Largen-overexpressing cells. Furthermore, Largen overexpression led to increased cell size invivo, as revealed by analyses of conditional Largen transgenic mice. Our results establish Largen as an important link between mRNA translation, mitochondrial functions, and the control of mammalian cell size. | |||||
書誌情報 |
Molecular Cell 巻 53, 号 6, p. 904-915, 発行日 2014-03-20 |
|||||
出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10972765 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.molcel.2014.02.028 | |||||
権利 | ||||||
権利情報 | c 2014 Elsevier Inc. All rights reserved. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Molecular Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular Cell, 53, 6, (2014) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Molecular Cell, 53(6), pp.904-915; 2014 |