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Molecular contribution to cleft palate production in cleft lip mice
http://hdl.handle.net/10069/34437
http://hdl.handle.net/10069/3443756e9b98c-e50c-4bb6-a3d6-e6ffe71c63c8
名前 / ファイル | ライセンス | アクション |
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ConAno54_94.pdf (515.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-05 | |||||
タイトル | ||||||
タイトル | Molecular contribution to cleft palate production in cleft lip mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CL/Fr mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cleft palate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Embryology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Growth/development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Molecular biology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sasaki, Yasunori
× Sasaki, Yasunori× Taya, Yuji× Saito, Kan× Fujita, Kazuya× Aoba, Takaaki× Fujiwara, Taku |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cleft palate following cleft lip may include a developmental disorder during palatogenesis. CL/Fr mice fetuses, which develop cleft lip and palate spontaneously, have less capability for in vivo cell proliferation in palatal mesenchyme compared with CL/Fr normal fetuses. In order to know the changes of signaling molecules contributing to cleft palate morphogenesis following cleft lip, the mRNA expression profiles were compared in palatal shelves oriented vertically (before elevation) in CL/Fr fetuses with or without cleft lip. The changes in mRNA profile of cleft palate morphogenesis were presented in a microarray analysis, and genes were restricted to lists contributing to cleft palate development in CL/Fr fetuses with cleft lip. Four candidate genes (Ywhab, Nek2, Tacc1 and Frk) were linked in a gene network that associates with cell proliferation (cell cycle, MAPK, Wnt and Tgf beta pathways). Quantitative real-time RT-PCR highlighted the candidate genes that significantly changed in CL/Fr fetuses with cleft lip (Ywhab, Nek2 and Tacc1). The results of these molecular contributions will provide useful information for a better understanding of palatogenesis in cleft palate following cleft lip. Our data indicated the genetic contribution to cleft palate morphogenesis following cleft lip. | |||||
書誌情報 |
Congenital Anomalies 巻 54, 号 2, p. 94-99, 発行日 2014-05 |
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出版者 | ||||||
出版者 | 日本先天異常学会 | |||||
出版者別言語 | ||||||
Japanese Teratology Society | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09143505 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/cga.12038 | |||||
権利 | ||||||
権利情報 | c 2013 The Authors. Congenital Anomalies published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Teratology Society. | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Congenital Anomalies, 54(2), pp.94-99; 2014 |