WEKO3
アイテム
{"_buckets": {"deposit": "bdadc655-3709-4812-8cb2-6a8cb2fa3efd"}, "_deposit": {"created_by": 2, "id": "5475", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "5475"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00005475", "sets": ["30"]}, "author_link": ["23296", "23298", "23300", "23294", "23299", "23293", "23295", "23297"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-06-14", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "22", "bibliographicPageEnd": "7074", "bibliographicPageStart": "7067", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "World Journal of Gastroenterology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosuppressant medication and liver fibrosis. The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy. The number of α-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy. In addition, the α-SMA-positive area evaluated using the Win- RooF image processing software program continued to increase over time in three adult transplanted patients with liver fibrosis, and the α-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases, according to a retrospective review. Therefore, α-SMA could be a useful marker for the detection of early stage fibrosis.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "World Journal of Gastroenterology, 20(22), pp.7067-7074; 2014", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "WJG Press"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3748/wjg.v20.i22.7067", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c1995-2014 Baishideng Publishing Group Inc. All rights reserved. Articles published by this open-access journal are distributed under the terms of the Creative Commons Attribution-Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "10079327", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hirabaru, Masataka"}], "nameIdentifiers": [{"nameIdentifier": "23293", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mochizuki, Kyoko"}], "nameIdentifiers": [{"nameIdentifier": "23294", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takatsuki, Mitsuhisa"}], "nameIdentifiers": [{"nameIdentifier": "23295", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Soyama, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "23296", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kosaka, Taiichiro"}], "nameIdentifiers": [{"nameIdentifier": "23297", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroki, Tamotsu"}], "nameIdentifiers": [{"nameIdentifier": "23298", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimokawa, Isao"}], "nameIdentifiers": [{"nameIdentifier": "23299", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi, Susumu"}], "nameIdentifiers": [{"nameIdentifier": "23300", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "WJG20_7067.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "WJG20_7067.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/5475/files/WJG20_7067.pdf"}, "version_id": "6e034cca-3e6a-43f8-ac66-540552c3207f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Alpha smooth muscle actin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hepatic stellate cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Immunosuppressant therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Liver fibrosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Living donor liver transplantation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Expression of alpha smooth muscle actin in living donor liver transplant recipients", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Expression of alpha smooth muscle actin in living donor liver transplant recipients"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/34553", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-07-23"}, "publish_date": "2014-07-23", "publish_status": "0", "recid": "5475", "relation": {}, "relation_version_is_last": true, "title": ["Expression of alpha smooth muscle actin in living donor liver transplant recipients"], "weko_shared_id": -1}
Expression of alpha smooth muscle actin in living donor liver transplant recipients
http://hdl.handle.net/10069/34553
http://hdl.handle.net/10069/34553513478a2-9267-47a1-b670-c72bd4243fd1
名前 / ファイル | ライセンス | アクション |
---|---|---|
WJG20_7067.pdf (1.5 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-07-23 | |||||
タイトル | ||||||
タイトル | Expression of alpha smooth muscle actin in living donor liver transplant recipients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alpha smooth muscle actin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hepatic stellate cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunosuppressant therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Living donor liver transplantation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hirabaru, Masataka
× Hirabaru, Masataka× Mochizuki, Kyoko× Takatsuki, Mitsuhisa× Soyama, Akihiko× Kosaka, Taiichiro× Kuroki, Tamotsu× Shimokawa, Isao× Eguchi, Susumu |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosuppressant medication and liver fibrosis. The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy. The number of α-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy. In addition, the α-SMA-positive area evaluated using the Win- RooF image processing software program continued to increase over time in three adult transplanted patients with liver fibrosis, and the α-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases, according to a retrospective review. Therefore, α-SMA could be a useful marker for the detection of early stage fibrosis. | |||||
書誌情報 |
World Journal of Gastroenterology 巻 20, 号 22, p. 7067-7074, 発行日 2014-06-14 |
|||||
出版者 | ||||||
出版者 | WJG Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10079327 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3748/wjg.v20.i22.7067 | |||||
権利 | ||||||
権利情報 | c1995-2014 Baishideng Publishing Group Inc. All rights reserved. Articles published by this open-access journal are distributed under the terms of the Creative Commons Attribution-Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | World Journal of Gastroenterology, 20(22), pp.7067-7074; 2014 |