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Alfacalcidol enhances collagen quality in ovariectomized rat bones
http://hdl.handle.net/10069/34713
http://hdl.handle.net/10069/34713e3b41e1e-af81-4f01-b92f-b994eaba3c75
名前 / ファイル | ライセンス | アクション |
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JOR32_1030.pdf (359.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-09-30 | |||||
タイトル | ||||||
タイトル | Alfacalcidol enhances collagen quality in ovariectomized rat bones | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alfacalcidol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | collagen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | collagen cross-link | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ovariectomized rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vitamin D | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nagaoka, Hideaki
× Nagaoka, Hideaki× Terajima, Masahiko× Yamada, Shizuka× Azuma, Yoshiaki× Chida, Takayuki× Yamauchi, Mitsuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to investigate the effects of alfacalcidol (1α(OH)D3: ALF) on bone collagen employing an ovariectomized rat model. Thirty-five 16-week-old female Sprague-Dawley rats were divided into five groups: SHAM (sham-operated-+-vehicle), OVX (ovariectomy-+-vehicle), and three ALF-treated groups, that is, ovariectomy-+-0.022-μg/kg/day ALF, ovariectomy-+-0.067-μg/kg/day ALF, and ovariectomy-+-0.2-μg/kg/day ALF. After 12 weeks of treatment, tibiae were subjected to histological, biochemical and immunohistochemical analyses. Collagen matrices in OVX bone appeared as immature and poorly organized; however, with the ALF treatment, it was improved in a dose-dependent manner. Contents of collagen and pyridinoline cross-link were decreased in OVX compared with SHAM, but they increased to the level comparable to SHAM in ALF-treated groups. The total aldehyde, that is, a sum of free and those involved cross-links, in the highest dose of ALF was significantly higher than the rest of the groups (p-<-0.05). In addition, the expression of lysyl oxidase was increased in the all ALF-treated groups compared with OVX (p-<-0.05). In conclusion, ALF increases not only the amount of collagen but also enhances the maturation of collagen in ovariectomy-induced osteoporotic bones, which likely contributes to the improvement of bone quality. | |||||
書誌情報 |
Journal of Orthopaedic Research 巻 32, 号 8, p. 1030-1036, 発行日 2014-08 |
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出版者 | ||||||
出版者 | John Wiley and Sons Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 07360266 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/jor.22642 | |||||
権利 | ||||||
権利情報 | c 2014 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Orthopaedic Research, 32(8), pp.1030-1036; 2014 |