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Prognostic Value of Podoplanin Expression in Oral Squamous Cell Carcinoma―A Regression Model Auxiliary to UICC Classification
http://hdl.handle.net/10069/34714
http://hdl.handle.net/10069/3471464f6debc-83b7-44a8-aa15-1b31c1715c92
名前 / ファイル | ライセンス | アクション |
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POR20_521.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-08-01 | |||||
タイトル | ||||||
タイトル | Prognostic Value of Podoplanin Expression in Oral Squamous Cell Carcinoma―A Regression Model Auxiliary to UICC Classification | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clinical stage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oral squamous cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Podoplanin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prognosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Statistical analysis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Seki, Sachiko
× Seki, Sachiko× Fujiwara, Mutsunori× Matsuura, Masaaki× Fujita, Shuichi× Ikeda, Hisazumi× Umeda, Masahiro× Asahina, Izumi× Ikeda, Tohru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Podoplanin, a type I transmembrane glycoprotein with an effect of platelet aggregation, has been reported to be one of the possible prognostic factors of oral squamous cell carcinoma (OSCC). However, the biological significance of podoplanin is largely unclear. The aim of this study was to develop a practical model for the prediction of prognosis using the grade of podoplanin expression, and also to evaluate the biological function of podoplanin. Eighty-two specimens of patients with previously untreated OSCC, who underwent either biopsy or surgery, were histopathologically and immunohistochemically analyzed. These 82 cases were composed of 66 well-differentiated, 10 moderately differentiated and 6 poorly differentiated OSCC. Podoplanin was successfully immunostained in 78 specimens, and was detected in most cases, but the frequency of positive cells varied. The prognosis of patients with more than 50 % podoplanin-positive tumor cells was significantly poorer than that of the other patients. Multivariate hazards regression analysis suggested that a linear combination of covariates, OSCC patients with more or less than 50 % podoplanin expression, age of more or less than 70 years old, mode of invasion and T3, T4 or T2 versus T1 of the UICC T-stage classification was the most effective model for evaluating the prognosis of OSCC patients. Additionally, podoplanin expression had a significant relationship to UICC clinical stage and the expression of Ki-67. An effective regression model using podoplanin expression was developed for evaluating the prognosis of OSCC and the biological significance of podoplanin was suggested to be associated with the growth and/or progression of OSCC. | |||||
書誌情報 |
Pathology & Oncology Research 巻 20, 号 3, p. 521-528, 発行日 2014-07 |
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出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 12194956 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15322807 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12253-013-9723-0 | |||||
権利 | ||||||
権利情報 | c 2013 Aranyi Lajos Foundation. | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Pathology & Oncology Research, 20(3), pp.521-528; 2014 |