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Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B
http://hdl.handle.net/10069/34779
http://hdl.handle.net/10069/34779999a29cc-2540-4ce8-9270-d62cd6b7cc5a
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Supplement.pdf (620.9 kB)
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Leukemia28_1459.pdf (926.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-02-01 | |||||
タイトル | ||||||
タイトル | Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acute myeloid leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA methylation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA methyltransferase 3 beta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myeloperoxidase | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Itonaga, Hidehiro
× Itonaga, Hidehiro× Imanishi, Daisuke× Wong, Yan-Fung× Sato, Shinya× Ando, Koji× Sawayama, Yasushi× Sasaki, Daisuke× Tsuruda, Kazuto× Hasegawa, Hiroo× Imaizumi, Yoshitaka× Taguchi, Jun× Tsushima, Hideki× Yoshida, Shinichiro× Fukushima, Takuya× Hata, Tomoko× Moriuchi, Yukiyoshi× Yanagihara, Katsunori× Miyazaki, Yasushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Myeloperoxidase (MPO) has been associated with both a myeloid lineage commitment and favorable prognosis in patients with acute myeloid leukemia (AML). DNA methyltransferase inhibitors (decitabine and zeburaline) induced MPO gene promoter demethylation and MPO gene transcription in AML cells with low MPO activity. Therefore, MPO gene transcription was directly and indirectly regulated by DNA methylation. A DNA methylation microarray subsequently revealed a distinct methylation pattern in 33 genes, including DNA methyltransferase 3 beta (DNMT3B), in CD34-positive cells obtained from AML patients with a high percentage of MPO-positive blasts. Based on the inverse relationship between the methylation status of DNMT3B and MPO, we found an inverse relationship between DNMT3B and MPO transcription levels in CD34-positive AML cells (P=0.0283). In addition, a distinct methylation pattern was observed in five genes related to myeloid differentiation or therapeutic sensitivity in CD34-positive cells from AML patients with a high percentage of MPO-positive blasts. Taken together, the results of the present study indicate that MPO may serve as an informative marker for identifying a distinct and crucial DNA methylation profile in CD34-positive AML cells. | |||||
書誌情報 |
Leukemia 巻 28, 号 7, p. 1459-1466, 発行日 2014-07 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08876924 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14765551 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/leu.2014.15 | |||||
権利 | ||||||
権利情報 | c 2014 Macmillan Publishers Limited. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Leukemia, 28(7), pp.1459-1466; 2014 |