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Although euthyroid\nshould be desirable to ensure a safe operation, some patients still undergo thyroidectomy with hyperthyroidism. The aim\nof this study was to evaluate our preoperative strategies in patients with Graves\u0027 disease. A total of 186 patients underwent thyroidectomy for Graves\u0027 disease between 2003 and 2017. We gave all of these patients potassium iodide (KI) in order to\ndecrease their thyroid hormone levels. We compared the clinical factors among three groups defined by the value of serum\nfree triiodothyronine (FT3) after the administration of KI: (1) the good control group (n=126) with ?6.0 pg/mL, (2) the fair control group (n=35) with \u003e6.0 but ?10.0 pg/mL, and (3) the poor control group (n=25) with \u003e10.0 pg/mL. KI decreased the serum\nlevels of thyroid hormone. However, some patients still had hyperthyroidism, and the subsequent administration of corticosteroid\nreduced FT3 but not thyroxine. Regarding the intraoperative course, the heart rate at 1 h after beginning general anesthesia\nwas higher in the poor control group than in the good control group (p\u003c0.05), and the proportion of patients given\nadrenergic beta-blocker was higher in the poor control group than in the other groups (p\u003c0.01 each). One patient in the fair\ncontrol group experienced suspected thyroid storm after total thyroidectomy. The occurrence rate of other deteriorations was\nidentical among the three groups. 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The preoperative thyroid function and perioperative course in patients with Graves' disease
http://hdl.handle.net/10069/39741
http://hdl.handle.net/10069/397416ff7adf6-c8ad-40e6-9808-3d4e5e24086f
名前 / ファイル | ライセンス | アクション |
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ActMed63_79.pdf (618.7 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2020-03-27 | |||||
タイトル | ||||||
タイトル | The preoperative thyroid function and perioperative course in patients with Graves' disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graves' disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroidectomy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid hormone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | iodine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid storm | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | corticosteroid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yamanouchi, Kosho
× Yamanouchi, Kosho× Kuba, Sayaka× Sakimura, Chika× Morita, Michi× Hayashida, Naomi× Kanetaka, Kengo× Takatsuki, Mitsuhisa× Eguchi, Susumu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Graves' disease is an autoimmune disorder that induces increase in thyroid hormone production and release. Although euthyroid should be desirable to ensure a safe operation, some patients still undergo thyroidectomy with hyperthyroidism. The aim of this study was to evaluate our preoperative strategies in patients with Graves' disease. A total of 186 patients underwent thyroidectomy for Graves' disease between 2003 and 2017. We gave all of these patients potassium iodide (KI) in order to decrease their thyroid hormone levels. We compared the clinical factors among three groups defined by the value of serum free triiodothyronine (FT3) after the administration of KI: (1) the good control group (n=126) with ?6.0 pg/mL, (2) the fair control group (n=35) with >6.0 but ?10.0 pg/mL, and (3) the poor control group (n=25) with >10.0 pg/mL. KI decreased the serum levels of thyroid hormone. However, some patients still had hyperthyroidism, and the subsequent administration of corticosteroid reduced FT3 but not thyroxine. Regarding the intraoperative course, the heart rate at 1 h after beginning general anesthesia was higher in the poor control group than in the good control group (p<0.05), and the proportion of patients given adrenergic beta-blocker was higher in the poor control group than in the other groups (p<0.01 each). One patient in the fair control group experienced suspected thyroid storm after total thyroidectomy. The occurrence rate of other deteriorations was identical among the three groups. With preparative KI and corticosteroid administration, almost all patients with Graves' disease were able to undergo thyroidectomy safely. |
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書誌情報 |
Acta medica Nagasakiensia 巻 63, 号 2, p. 79-86, 発行日 2020-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
04 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 63(2), pp.79-86; 2020 |