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Protein trafficking in Plasmodium falciparum-infected red cells and impact of the expansion of exported protein families
http://hdl.handle.net/10069/34830
http://hdl.handle.net/10069/34830145bd9b4-a4fa-4c40-a19b-24cd7ebc00c6
名前 / ファイル | ライセンス | アクション |
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Par140_580.pdf (565.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-11-01 | |||||
タイトル | ||||||
タイトル | Protein trafficking in Plasmodium falciparum-infected red cells and impact of the expansion of exported protein families | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | erythrocyte remodelling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | exported proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene family expansion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium falciparum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein trafficking | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Prajapati, Surendra Kumar
× Prajapati, Surendra Kumar× Culleton, Richard× Singh, Om Prakash |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Erythrocytes are extensively remodelled by the malaria parasite following invasion of the cell. Plasmodium falciparum encodes numerous virulence-associated and host-cell remodelling proteins that are trafficked to the cytoplasm, the cell membrane and the surface of the infected erythrocyte. The export of soluble proteins relies on a sequence directing entry into the secretory pathways in addition to an export signal. The export signal consisting of five amino acids is termed the Plasmodium export element (PEXEL) or the vacuole transport signal (VTS). Genome mining studies have revealed that PEXEL/VTS carrying protein families have expanded dramatically in P. falciparum compared with other malaria parasite species, possibly due to lineage-specific expansion linked to the unique requirements of P. falciparum for host-cell remodelling. The functional characterization of such genes and gene families may reveal potential drug targets that could inhibit protein trafficking in infected erythrocytes. This review highlights some of the recent advances and key knowledge gaps in protein trafficking pathways in P. falciparum-infected red cells and speculates on the impact of exported gene families in the trafficking pathway. | |||||
書誌情報 |
Parasitology 巻 141, 号 12, p. 1533-1543, 発行日 2014-10 |
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出版者 | ||||||
出版者 | Cambridge University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00311820 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14698161 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1017/S0031182014000948 | |||||
権利 | ||||||
権利情報 | c Cambridge University Press 2014. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Parasitology, 141(12), pp.1533-1543; 2014 |