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Pilot Study on Interferon-γ-producing T Cell Subsets after the Protective Vaccination with Radiation-attenuated Cercaria of Schistosoma japonicum in the Miniature Pig Model
http://hdl.handle.net/10069/34942
http://hdl.handle.net/10069/34942809b7cae-99a0-4372-9b5a-a6a4074b65ac
名前 / ファイル | ライセンス | アクション |
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TMH42_155.pdf (645.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-12-10 | |||||
タイトル | ||||||
タイトル | Pilot Study on Interferon-γ-producing T Cell Subsets after the Protective Vaccination with Radiation-attenuated Cercaria of Schistosoma japonicum in the Miniature Pig Model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IFN-γ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Miniature pig | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation attenuated cercaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Schistosoma japonicum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | αβ T cell receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γδ T cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Abdel-Hafeez, Ekhlas Hamed
× Abdel-Hafeez, Ekhlas Hamed× Watanabe, Kanji× Kamei, Kaori× Kikuchi, Mihoko× Chen, Honggen× Daniel, Boamah× Yu, Chuanxin× Hirayama, Kenji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | CLAWN miniature pig has been shown to serve as a suitable host for the experimental infection of Schistosoma japonicum. In this study, we found that radiation-attenuated cercaria (RAC) vaccine gave CLAWN miniature pigs protective immunity against subsequent challenge infection with S. japonicum cercaria. To characterize the protective immune response of the pig model vaccinated by attenuated cercaria, flow cytometric analysis of the reactive T cell subsets was performed. The intracellular interferon (IFN)-γ and the cell surface markers revealed the peripheral blood CD3+ T-lymphocytes produced significant amounts of IFN-γ during the immunization period and after the challenge infection. CD4+ αβ-T cells as well as CD4+/CD8αmid double positive and/or CD8αhigh αβ-T cells were the major IFN-γ-producing CD3+ T cells. On the contrary, γδ T cells did not produce intracellular IFN-γ. Our results suggested that RAC-vaccinated miniature pigs showed effective protective immunity through the activation of αβ T cells bearing antigen specific T-cell receptors but not through the activation of γδ T cells. | |||||
書誌情報 |
Tropical Medicine and Health 巻 42, 号 4, p. 155-162, 発行日 2014-10-28 |
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出版者 | ||||||
出版者 | 日本熱帯医学会 | |||||
出版者別言語 | ||||||
Japanese Society of Tropical Medicine | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13488945 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2149/tmh.2014-11 | |||||
権利 | ||||||
権利情報 | c 2014 Japanese Society of Tropical Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health, 42(4), pp.155-162; 2014 |