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ヒト培養細胞由来と酵母由来遺伝子組換えB型肝炎ワクチンの効果の比較
http://hdl.handle.net/10069/35041
http://hdl.handle.net/10069/3504178446c04-1dd4-4098-922b-47e61713fe32
名前 / ファイル | ライセンス | アクション |
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hokenn27_21.pdf (464.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-01-23 | |||||
タイトル | ||||||
タイトル | ヒト培養細胞由来と酵母由来遺伝子組換えB型肝炎ワクチンの効果の比較 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | B 型肝炎ワクチン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HBs抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HBs抗原 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 看護学生 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hepatitis B vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anti-HBs | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HBsAg | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nursing students | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
田代, 隆良
× 田代, 隆良× 田中, 千明× 疋田, 桂子× 緒方, 優衣× 西崎, 仁美× 田代, 将人× 石松, 祐二× 泉川, 公一 |
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著者別名 | ||||||
姓名 | Tashiro, Takayoshi | |||||
著者別名 | ||||||
姓名 | Tanaka, Chiaki | |||||
著者別名 | ||||||
姓名 | Hikita, Keiko | |||||
著者別名 | ||||||
姓名 | Ogata, Yui | |||||
著者別名 | ||||||
姓名 | Nishizaki, Hitomi | |||||
著者別名 | ||||||
姓名 | Tashiro, Masato | |||||
著者別名 | ||||||
姓名 | Ishimatsu, Yuji | |||||
著者別名 | ||||||
姓名 | Izumikawa, Koichi | |||||
その他のタイトル | ||||||
その他のタイトル | Comparison of efficacy of human cell-derived and yeast-derived recombinant hepatitis B vaccines | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 2000 ~ 2013年度に入学した長崎大学看護学生1,000名のHBs抗原とHBs抗体を検査した.HBs抗原陽性率は0.10%(2000 ~ 2004年0.27%,2005 ~ 2013年0.0%),HBs抗体陽性率は1.80%(2000 ~ 2004年1.08%,2005 ~ 2013年2.22%)だった.HBs抗原・HBs抗体とも陰性だった970名に対しヒト培養細胞由来遺伝子組換え沈降 B 型肝炎ワクチン「明乳」(Mワクチン)または酵母由来遺伝子組換え沈降 B 型肝炎ワクチン「ビームゲン」(B ワクチン)を接種した.ワクチン接種後のHBs抗体獲得率は,Mワクチン接種者(n=563)98.0%,B ワクチン接種者(n=407)99.0%と変わりないが,HBs抗体価中央値は,2120.0mIU/mL,313.0mIU/mLとMワクチン接種者が有意差に高かった.HBs抗体価は経年的に低下し,ワクチン接種後の抗体価が低い者はより早期に陰性となった.すなわち,HBs抗体陽性持続期間はMワクチン接種者が B 接種者より長かった. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A total of 1,000 nursing students of Nagasaki University School of Health Sciences were examined for serum HBsAg and anti-HBs at their first year between 2000 and 2013. The prevalence of HBsAg was 0.10%; 0.27% in 2000-2004 and 0.0% in 2005-2013. The prevalence of anti-HBs was 1.80%; 1.08 % in 2000-2004 and 2.22% in 2005-2013. A total of 970 students who were negative for HBsAg and anti-HBs received a primary series of hepatitis B vaccinations with human cell-derived recombinant vaccines (Meinyu) or yeast-derived recombinant vaccines (Bimmugen). Subsequently, 98.0% by Meinyu (n=563)and 99.0% by Bimmugen( n=407) acquired anti-HBs titers over 10 mIU/mL. The median titers of anti-HBs in Meinyu recipients( 2120.0 mIU/mL) were significantly higher than those in Bimmugen recipients (313.0 mIU/mL). The anti-HBs titers were declined with time following vaccination, and the decline seemed to depend on the titer originally obtained. Thus, Meinyu recipients may have more persistence of anti-HBs titers over 10 mIU/mL than Bimmugen recipients. |
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書誌情報 |
保健学研究 en : Health Science Research 巻 27, p. 21-27, 発行日 2015-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18814441 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12200909 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 長崎大学大学院医歯薬学総合研究科保健学専攻 | |||||
出版者別言語 | ||||||
Master Course of Health Sciences Graduate School of Biomedical Sciences Nagasaki University | ||||||
sortkey | ||||||
03 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 保健学研究, 27, pp.21-27; 2015 |