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Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation
http://hdl.handle.net/10069/35125
http://hdl.handle.net/10069/35125f663cdcb-bf88-40ef-b8a6-b8b74fce2862
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PhyBe140_15.pdf (443.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-03-18 | |||||
| タイトル | ||||||
| タイトル | Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Genistein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Glucose load | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Oral administration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Phytoestrogen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Spatial learning | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kohara, Yumi
× Kohara, Yumi× Kawaguchi, Shinichiro× Kuwahara, Rika× Uchida, Yutaro× Oku, Yushi× Yamashita, Kimihiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cognitive dysfunction due to higher blood glucose level has been reported previously. Genistein (GEN) is a phytoestrogen that we hypothesized might lead to improved memory, despite elevated blood glucose levels at the time of memory consolidation. To investigate this hypothesis, we compared the effects of orally administered GEN on the central nervous system in normal versus glucose-loaded adult male rats. A battery of behavioral assessments was carried out. In the MAZE test, which measured spatial learning and memory, the time of normal rats was shortened by GEN treatment compared to the vehicle group, but only in the early stages of testing. In the glucose-loaded group, GEN treatment improved performance as mazes were advanced. In the open-field test, GEN treatment delayed habituation to the new environment in normal rats, and increased the exploratory behaviors of glucose-loaded rats. There were no significant differences observed for emotionality or fear-motivated learning and memory. Together, these results indicate that GEN treatment improved spatial learning and memory only in the early stages of testing in the normal state, but improved spatial learning and memory when glucose levels increased during memory consolidation. | |||||
| 書誌情報 |
Physiology & Behavior 巻 140, p. 15-22, 発行日 2015-03-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00319384 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.physbeh.2014.12.005 | |||||
| 権利 | ||||||
| 権利情報 | c 2014 Elsevier Inc. | |||||
| 権利 | ||||||
| 権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Physiology & Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Physiology & Behavior, 140, (2015) | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Physiology & Behavior, 140, pp.15-22; 2015 | |||||
