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Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens
http://hdl.handle.net/10069/32996
http://hdl.handle.net/10069/32996781b00b8-4eea-47ce-8adc-3ceb746e8637
名前 / ファイル | ライセンス | アクション |
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JID66_207.pdf (923.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-07-30 | |||||
タイトル | ||||||
タイトル | Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tuberculosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cell cytokine response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | latent infection | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamashita, Yoshiro
× Yamashita, Yoshiro× Hoshino, Yoshihiko× Oka, Mayuko× Matsumoto, Sokichi× Ariga, Haruyuki× Nagai, Hideaki× Makino, Masahiko× Ariyoshi, Koya× Tsunetsugu-Yokota, Yasuko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although IFN-γ release assays (IγRAs) provide increased specificity over tuberculin skin tests, the early and sensitive detection of reactivation of latently infected Mycobacterium tuberculosis is required to control tuberculosis (TB). Recently, a multicolor flow cytometry has been developed to study CD4+ T cell cytokine responses (IFN-γ/IL-2/TNF-a) to purified protein derivatives (PPD) and M. tuberculosis-specific antigens (ESAT-6/CFP-10) and provided useful information regarding anti-TB immunity. However, the diagnostic relevancy remains uncertain. Here, we analyzed three additional CD4+ T cell cytokine responses (IL-10/IL-13/IL-17) to latent mycobacterial antigens (a-crystallin, methylated heparin-binding hemagglutinin [HBHA], and mycobacterial DNA-binding protein 1 [MDP-1]) as well as PPD and ESAT-6/CFP-10 in 12 IGRA+ TB cases and 8 healthy controls. No significant difference in IFN-γ response was observed between TB cases and controls, which was likely due to the high variation among the individuals. However, we found a significant increase over healthy controls in (i) the IL-2 response to HBHA in recovery stage TB cases, (ii) the number of M. tuberculosisspecific polyfunctional CD4+ T cells in on-treatment and recovery stage cases, and (iii) the IL-17 response to HBHA and MDP-1 in on-treatment and recovery stage cases. These results suggest that a combination of these T cell cytokine parameters could aid in accurate diagnosis of latent TB infection. | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 66, 号 3, p. 207-215, 発行日 2013-05-23 |
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出版者 | ||||||
出版者 | 国立感染症研究所 | |||||
出版者別言語 | ||||||
National Institute of Infectious Diseases | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7883/yoken.66.207 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Journal of Infectious Diseases, 66(3), pp.207-215; 2013 |