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In vitro antioxidant activities of sulfated polysaccharide ascophyllan isolated from Ascophyllum nodosum
http://hdl.handle.net/10069/33043
http://hdl.handle.net/10069/33043c689a122-4306-4ccd-9028-2bb396a57fd1
名前 / ファイル | ライセンス | アクション |
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IJBM59_305.pdf (506.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-07-31 | |||||
タイトル | ||||||
タイトル | In vitro antioxidant activities of sulfated polysaccharide ascophyllan isolated from Ascophyllum nodosum | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antioxidant activities | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ascophyllan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fucoidan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydroxyl radical scavenging activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reducing power | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Superoxide scavenging activity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Abu, Ryogo
× Abu, Ryogo× Jiang, Zedong× Ueno, Mikinori× Okimura, Takasi× Yamaguchi, Kenichi× Oda, Tatsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antioxidant activities of sulfated polysaccharide ascophyllan from Ascophyllum nodosum was investigated in vitro by various assays, and compared with those of fucoidan. A chemiluminescence (CL) analysis using a luminol analog, L-012, showed that ascophyllan scavenges superoxide, and the activity is greater than fucoidan. However, in the presence of 10μg/ml of ascophyllan or 10μg/ml and 100μg/ml of fucoidan, slightly enhanced CL-responses were observed. Since EDTA-treatment resulted in disappearance of the enhancement effects, it was suggested that metal ions especially iron ions in the polysaccharides might be involved in this phenomenon. In fact, metal element analysis revealed that ascophyllan and fucoidan inherently contain iron and other metal elements. EDTA-treatment resulted in significant increase in Fe2+-chelating activities of these polysaccharides. In an electron spin resonance (ESR)-spin trapping analysis in which direct UV-radiation to hydrogen peroxide was used as a source of hydroxyl radical, ascophyllan and fucoidan showed potent hydroxyl radical scavenging activity with similar extent. Reducing power of ascophyllan was stronger than that of fucoidan. Our results indicate that ascophyllan can exhibit direct and potent antioxidant activity. | |||||
書誌情報 |
International Journal of Biological Macromolecules 巻 59, p. 305-312, 発行日 2013-08 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01418130 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijbiomac.2013.04.035 | |||||
権利 | ||||||
権利情報 | © 2013 Elsevier B.V. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Biological Macromolecules. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Biological Macromolecules, 59(2013) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Biological Macromolecules, 59, pp.305-312; 2013 |