WEKO3
アイテム
{"_buckets": {"deposit": "8666fad0-c051-483f-ae4a-abdaeb269b26"}, "_deposit": {"created_by": 2, "id": "6460", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "6460"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00006460", "sets": ["9"]}, "author_link": ["27473", "27477", "27487", "27481", "27482", "27480", "27475", "27479", "27476", "27472", "27478", "27474", "27483", "27484", "27485", "27486"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-07-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageStart": "e67739", "bibliographicVolumeNumber": "8", "bibliographic_titles": [{"bibliographic_title": "PLoS ONE"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background:The purpose of this study was to determine whether autologous mesenchymal stem cells (MSCs) implantation improves endothelial dysfunction in a rabbit ischemic limb model.Methods:We evaluated the effect of MSC implantation on limb blood flow (LBF) responses to acetylcholine (ACh), an endothelium-dependent vasodilator, and sodium nitroprusside (SNP), an endothelium-independent vasodilator, in rabbits with limb ischemia in which cultured MSCs were implanted (n = 20) or saline was injected as a control group (n = 20). LBF was measured using an electromagnetic flowmeter. A total of 106 MSCs were implanted into each ischemic limb.Results:Histological sections of ischemic muscle showed that capillary index (capillary/muscle fiber) was greater in the MSC implantation group than in the control group. Laser Doppler blood perfusion index was significantly increased in the MSC implantation group compared with that in the control group. LBF response to ACh was greater in the MSC group than in the control group. After administration of NG-nitro-L-arginine, a nitric oxide synthase inhibitor, LBF response to ACh was similar in the MSC implantation group and control group. Vasodilatory effects of SNP in the two groups were similar.Conclusions:These findings suggest that MSC implantation induces angiogenesis and augments endothelium-dependent vasodilation in a rabbit ischemic model through an increase in nitric oxide production.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "PLoS ONE, 8(7), e67739; 2013", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Public Library of Science"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1371/journal.pone.0067739", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2013 Mikami et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "19326203", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mikami, Shinsuke"}], "nameIdentifiers": [{"nameIdentifier": "27472", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, Ayumu"}], "nameIdentifiers": [{"nameIdentifier": "27473", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagawa, Keigo"}], "nameIdentifiers": [{"nameIdentifier": "27474", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruhashi, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "27475", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwamoto, Yumiko"}], "nameIdentifiers": [{"nameIdentifier": "27476", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kajikawa, Masato"}], "nameIdentifiers": [{"nameIdentifier": "27477", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "27478", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kihara, Yasuki"}], "nameIdentifiers": [{"nameIdentifier": "27479", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chayama, Kazuaki"}], "nameIdentifiers": [{"nameIdentifier": "27480", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Noma, Kensuke"}], "nameIdentifiers": [{"nameIdentifier": "27481", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ochi, Mitsuo"}], "nameIdentifiers": [{"nameIdentifier": "27482", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishimura, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "27483", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuji, Koichiro"}], "nameIdentifiers": [{"nameIdentifier": "27484", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "27485", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Goto, Chikara"}], "nameIdentifiers": [{"nameIdentifier": "27486", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higashi, Yukihito"}], "nameIdentifiers": [{"nameIdentifier": "27487", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PLoS8_67739.pdf", "filesize": [{"value": "4.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4200000.0, "url": {"label": "PLoS8_67739.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/6460/files/PLoS8_67739.pdf"}, "version_id": "34fad0ed-511c-41c0-9a95-b9ca941b831b"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model"}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/33416", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-08-23"}, "publish_date": "2013-08-23", "publish_status": "0", "recid": "6460", "relation": {}, "relation_version_is_last": true, "title": ["Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model"], "weko_shared_id": -1}
Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model
http://hdl.handle.net/10069/33416
http://hdl.handle.net/10069/33416efa2b7e9-09a6-4c01-807d-f3662d016bf0
名前 / ファイル | ライセンス | アクション |
---|---|---|
PLoS8_67739.pdf (4.2 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-08-23 | |||||
タイトル | ||||||
タイトル | Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mikami, Shinsuke
× Mikami, Shinsuke× Nakashima, Ayumu× Nakagawa, Keigo× Maruhashi, Tatsuya× Iwamoto, Yumiko× Kajikawa, Masato× Matsumoto, Takeshi× Kihara, Yasuki× Chayama, Kazuaki× Noma, Kensuke× Ochi, Mitsuo× Nishimura, Masahiro× Tsuji, Koichiro× Kato, Yukio× Goto, Chikara× Higashi, Yukihito |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background:The purpose of this study was to determine whether autologous mesenchymal stem cells (MSCs) implantation improves endothelial dysfunction in a rabbit ischemic limb model.Methods:We evaluated the effect of MSC implantation on limb blood flow (LBF) responses to acetylcholine (ACh), an endothelium-dependent vasodilator, and sodium nitroprusside (SNP), an endothelium-independent vasodilator, in rabbits with limb ischemia in which cultured MSCs were implanted (n = 20) or saline was injected as a control group (n = 20). LBF was measured using an electromagnetic flowmeter. A total of 106 MSCs were implanted into each ischemic limb.Results:Histological sections of ischemic muscle showed that capillary index (capillary/muscle fiber) was greater in the MSC implantation group than in the control group. Laser Doppler blood perfusion index was significantly increased in the MSC implantation group compared with that in the control group. LBF response to ACh was greater in the MSC group than in the control group. After administration of NG-nitro-L-arginine, a nitric oxide synthase inhibitor, LBF response to ACh was similar in the MSC implantation group and control group. Vasodilatory effects of SNP in the two groups were similar.Conclusions:These findings suggest that MSC implantation induces angiogenesis and augments endothelium-dependent vasodilation in a rabbit ischemic model through an increase in nitric oxide production. | |||||
書誌情報 |
PLoS ONE 巻 8, 号 7, p. e67739, 発行日 2013-07-04 |
|||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0067739 | |||||
権利 | ||||||
権利情報 | © 2013 Mikami et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS ONE, 8(7), e67739; 2013 |