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Production and degradation of extracellular matrix in reversible glomerular lesions in rat model of habu snake venom-induced glomerulonephritis
http://hdl.handle.net/10069/33636
http://hdl.handle.net/10069/336369bd0b21d-e53e-4c71-83d9-e0287f91bb2b
名前 / ファイル | ライセンス | アクション |
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MMM45_190.pdf (497.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-09-11 | |||||
タイトル | ||||||
タイトル | Production and degradation of extracellular matrix in reversible glomerular lesions in rat model of habu snake venom-induced glomerulonephritis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Extracellular matrix (ECM) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type IV collagen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HSP47 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MMP-3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ets-1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawazu, Tayo
× Kawazu, Tayo× Nishino, Tomoya× Obata, Yoko× Furusu, Akira× Miyazaki, Masanobu× Abe, Katsushige× Koji, Takehiko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the mechanism of development and repair process of glomerular injury in a rat model of habu snake (Trimeresurus flavoviridis) venom (HSV)-induced glomerulonephritis. Glomerulonephritis was induced in rats by intravenously injecting HSV at 3 mg/kg. Renal tissue was isolated and subjected to immunohistochemical analysis for expression levels of type IV collagen, heat shock protein 47 (HSP47), transforming growth factor-β (TGF-β), and matrix metalloproteinase-3 (MMP-3), as well as its transcription factor Ets-1. Expression levels of HSP47, TGF-β, and type IV collagen began to increase in the mesangial area starting from day 14 and peaked on day 21, followed by a gradual decrease. Expression levels of MMP-3 and Ets-1 started to increase coinciding with peak production of mesangial matrix on day 21, peaking on day 35, followed by gradual decrease. Expression of MMP-3 and Ets-1 persisted until day 63, whereas that of HSP47 and type IV collagen returned to baseline level at this time point. Time-course changes of extracellular matrix (ECM) accumulation in glomeruli in the HSV-induced glomerulonephritis model were correlated with those of factors involved in both ECM production and degradation systems. Continued expression of factors in the degradation system seems particularly important for the repair process. These findings might lead to new therapies that prevent and repair glomerular injury. | |||||
書誌情報 |
Medical Molecular Morphology 巻 45, 号 4, p. 190-198, 発行日 2012-12 |
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出版者 | ||||||
出版者 | 日本臨床分子形態学会 | |||||
出版者別言語 | ||||||
Japanese Society for Clinical Molecular Morphology | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18601480 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18601499 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00795-011-0559-y | |||||
権利 | ||||||
権利情報 | © 2012 The Japanese Society for Clinical Molecular Morphology | |||||
権利 | ||||||
権利情報 | The final publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/28709 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medical Molecular Morphology, 45(4), pp.190-198; 2012 |