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Effects of programmed intermittent thoracic paravertebral bolus of levobupivacaine on the spread of sensory block: a randomized, controlled, double-blind study
http://hdl.handle.net/10069/40295
http://hdl.handle.net/10069/4029563e59a9c-e9b1-48aa-a831-152c327bd39b
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2020-09-25 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Effects of programmed intermittent thoracic paravertebral bolus of levobupivacaine on the spread of sensory block: a randomized, controlled, double-blind study | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | continuous infusion | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | levobupivacaine | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | programmed intermittent bolus | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | sensory block | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | thoracic paravertebral block | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
樋田, 久美子
× 樋田, 久美子
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著者別名 | ||||||||
姓名 | Hida, Kumiko | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Background and objectives: This randomized, controlled, double-blind trial compared the effectiveness of levobupivacaine delivery of a programmed intermittent paravertebral bolus with a continuous paravertebral infusion. Methods: Thirty-two consecutively enrolled patients who underwent unilateral video-assisted thoracic surgery were randomized to receive either a programmed intermittent paravertebral bolus of 10?mL of 0.2% levobupivacaine every 2?hours (Bolus group, n=16) or a continuous paravertebral infusion of 0.2% levobupivacaine at 5?mL/hour (Infusion group, n=16) after the operation. Postoperatively, after injection of 20?mL of 0.25% levobupivacaine through the paravertebral catheter, a mechanical infusion pump was set depending on the assigned group. The primary efficacy outcome was the number of anesthetized dermatomes 24?hours after the initial bolus of levobupivacaine. The secondary efficacy outcomes included the number of anesthetized dermatomes at other time points, pain at rest and coughing, additional analgesic use and patient acceptance of the analgesic technique. Arterial levobupivacaine concentration was measured to ensure safety. P<0.05 was considered statistically significant. Results: The mean (95% CI) number of anesthetized dermatomes 24?hours after the initial bolus of levobupivacaine was significantly larger among subjects receiving programmed intermittent bolus (n=16) compared with those receiving continuous infusion (n=16; 6.8 (5.7?7.9) vs 3.1 (2.0?4.2); p<0.001). The arterial levobupivacaine concentration did not reach a toxic level. Conclusions: The programmed intermittent paravertebral bolus of levobupivacaine provided a wider dermatomal spread of sensory block than continuous paravertebral infusion with an identical hourly dose of levobupivacaine. |
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内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)乙第58号 学位授与年月日:令和2年9月2日 | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Author: Kumiko Hida, Hiroaki Murata, Taiga Ichinomiya, Haruka Inoue, Shuntaro Sato and Tetsuya Hara | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Citation: Regional Anesthesia & Pain Medicine, 44(3), pp.326-332; 2019 | |||||||
書誌情報 |
Regional Anesthesia & Pain Medicine 巻 44, 号 3, p. 326-332, 発行日 2020-09-02 |
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ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 10987339 | |||||||
EISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 15328651 | |||||||
権利 | ||||||||
権利情報 | c American Society of Regional Anesthesia & Pain Medicine 2019. No commercial re-use. See rights and permissions. Published by BMJ. This article has been accepted for publication in Regional Anesthesia & Pain Medicine, 2019 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/rapm-2018-100021. |
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著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
その他のタイトル | ||||||||
その他のタイトル | 自動間欠的投与法を用いた胸部傍脊椎ブロックによる感覚遮断範囲の経時的変化に関する研究:ランダム化二重盲検群間試験 | |||||||
出版者 | ||||||||
出版者 | BMJ Publishing Group | |||||||
関係URI | ||||||||
識別子タイプ | HDL | |||||||
関連識別子 | http://hdl.handle.net/10069/40357 | |||||||
学位名 | ||||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 17301 | |||||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2020-09-02 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 乙医歯薬第58号 | |||||||
学位の種類 | ||||||||
論文博士 | ||||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2020-09-02) |