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Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population
http://hdl.handle.net/10069/33889
http://hdl.handle.net/10069/338890f7ce078-8b32-47a3-96a0-4c2bdc6310ba
名前 / ファイル | ライセンス | アクション |
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PLoS8_71382.pdf (110.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-10 | |||||
タイトル | ||||||
タイトル | Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Migita, Kiyoshi
× Migita, Kiyoshi× Nakamura, Minoru× Abiru, Seigo× Jiuchi, Yuka× Nagaoka, Shinya× Komori, Atsumasa× Hashimoto, Satoru× Bekki, Shigemune× Yamasaki, Kazumi× Komatsu, Tatsuji× Shimada, Masaaki× Kouno, Hiroshi× Hijioka, Taizo× Kohjima, Motoyuki× Nakamuta, Makoto× Kato, Michio× Yoshizawa, Kaname× Ohta, Hajime× Nakamura, Yoko× Takezaki, Eiichi× Nishimura, Hideo× Sato, Takeaki× Ario, Keisuke× Hirashima, Noboru× Oohara, Yukio× Naganuma, Atsushi× Muro, Toyokichi× Sakai, Hironori× Mita, Eiji× Sugi, Kazuhiro× Yamashita, Haruhiro× Makita, Fujio× Yatsuhashi, Hiroshi× Ishibashi, Hiromi× Yasunami, Michio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aims:Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 polymorphisms on the susceptibility and phenotype of type-1 autoimmune hepatitis in a Japanese National Hospital Organization (NHO) AIH multicenter cohort study.Methodology/Principal Findings:Genomic DNA from 460 individuals of Japanese origin including 230 patients with type-1 autoimmune hepatitis and 230 healthy controls was analyzed for two single nucleotide polymorphisms in the STAT4 gene (rs7574865, rs7582694). The STAT4 rs7574865T allele conferred risk for type-1 autoimmune hepatitis (OR = 1.61, 95% CI = 1.23-2.11; P = 0.001), and patients without accompanying autoimmune diseases exhibited an association with the rs7574865T allele (OR = 1.50, 95%CI = 1.13-1.99; P = 0.005). Detailed genotype-phenotype analysis of type-1 autoimmune hepatitis patients with (n = 44) or without liver cirrhosis (n = 186) demonstrated that rs7574865 was not associated with the development of liver cirrhosis and phenotype (biochemical data and the presence of auto-antibodies).Conclusions/Significance:This is the first study to show a positive association between a STAT4 polymorphism and type-1 autoimmune hepatitis, suggesting that autoimmune hepatitis shares a gene commonly associated with risk for other autoimmune diseases. | |||||
書誌情報 |
PLoS ONE 巻 8, 号 8, p. e71382, 発行日 2013-08-22 |
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出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0071382 | |||||
権利 | ||||||
権利情報 | © 2013 Migita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS ONE, 8(8), e71382; 2013 |