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Background Biomarkers predicting the presence of TCFA in vivo have not been established. Methods We evaluated 75 patients (stable angina pectoris, n = 47; acute coronary syndrome, n = 28) with de novo culprit lesions who were examined by optical coherence tomography and intravascular ultrasound. We defined TCFA as lipid-rich plaque with a fibrous cap \u003c65 μm thick. Systemic levels of PTX3 were compared between patients with and without TCFA. Results Thirty-eight and 37 patients with and without TCFA, respectively, were identified. Levels of PTX3 were significantly higher in patients with than in those without TCFA (p \u003c 0.001) and correlated inversely with fibrous cap thickness (r = -0.71, p = 0.001) and positively with the remodeling index (r = 0.25, p = 0.037). Multivariate logistic regression analysis showed that a higher PTX3 level was the most powerful predictor of TCFA (odds ratio: 3.26, 95% confidence interval: 1.75 to 6.05, p \u003c 0.001). Receiver-operating characteristic curve analysis showed that \u003e3.24 ng/ml of PTX3 could predict TCFA with 84% sensitivity and 86% specificity. Conclusions Higher levels of systemic PTX3 are associated with TCFA. Systemic PTX3 levels comprise a useful inflammatory marker that reflects coronary plaque vulnerability.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "JACC: Cardiovascular Interventions, 6(9), pp.945-954; 2013", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.jcin.2013.04.024", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2013 by the American College of Cardiology Foundation."}, {"subitem_rights": "NOTICE: this is the author’s version of a work that was accepted for publication in JACC: Cardiovascular Interventions. 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Elevated Levels of Systemic Pentraxin 3 Are Associated With Thin-Cap Fibroatheroma in Coronary Culprit Lesions : Assessment by Optical Coherence Tomography and Intravascular Ultrasound
http://hdl.handle.net/10069/33936
http://hdl.handle.net/10069/33936bfbb0960-70c6-49b5-a7b7-f41cf4fec67f
名前 / ファイル | ライセンス | アクション |
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JACC_CI6_945.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-31 | |||||
タイトル | ||||||
タイトル | Elevated Levels of Systemic Pentraxin 3 Are Associated With Thin-Cap Fibroatheroma in Coronary Culprit Lesions : Assessment by Optical Coherence Tomography and Intravascular Ultrasound | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | optical coherence tomography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pentraxin 3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thin-cap fibroatheroma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vulnerable plaque | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Koga, Seiji
× Koga, Seiji× Ikeda, Satoshi× Yoshida, Takeo× Nakata, Tomoo× Takeno, Masayoshi× Masuda, Nobuhito× Koide, Yuji× Kawano, Hiroaki× Maemura, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives This study sought to determine whether systemic levels of pentraxin 3 (PTX3), a novel inflammatory marker, are associated with thin-cap fibroatheroma (TCFA). Background Biomarkers predicting the presence of TCFA in vivo have not been established. Methods We evaluated 75 patients (stable angina pectoris, n = 47; acute coronary syndrome, n = 28) with de novo culprit lesions who were examined by optical coherence tomography and intravascular ultrasound. We defined TCFA as lipid-rich plaque with a fibrous cap <65 μm thick. Systemic levels of PTX3 were compared between patients with and without TCFA. Results Thirty-eight and 37 patients with and without TCFA, respectively, were identified. Levels of PTX3 were significantly higher in patients with than in those without TCFA (p < 0.001) and correlated inversely with fibrous cap thickness (r = -0.71, p = 0.001) and positively with the remodeling index (r = 0.25, p = 0.037). Multivariate logistic regression analysis showed that a higher PTX3 level was the most powerful predictor of TCFA (odds ratio: 3.26, 95% confidence interval: 1.75 to 6.05, p < 0.001). Receiver-operating characteristic curve analysis showed that >3.24 ng/ml of PTX3 could predict TCFA with 84% sensitivity and 86% specificity. Conclusions Higher levels of systemic PTX3 are associated with TCFA. Systemic PTX3 levels comprise a useful inflammatory marker that reflects coronary plaque vulnerability. | |||||
書誌情報 |
JACC: Cardiovascular Interventions 巻 6, 号 9, p. 945-954, 発行日 2013-09 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19368798 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jcin.2013.04.024 | |||||
権利 | ||||||
権利情報 | © 2013 by the American College of Cardiology Foundation. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in JACC: Cardiovascular Interventions. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in JACC: Cardiovascular Interventions, 6, 9(2013) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JACC: Cardiovascular Interventions, 6(9), pp.945-954; 2013 |