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Aβ Secretion and Plaque Formation Depend on Autophagy
http://hdl.handle.net/10069/33972
http://hdl.handle.net/10069/3397232b83778-973e-41e7-9f1b-f35a277abac5
名前 / ファイル | ライセンス | アクション |
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CelRep5_61.pdf (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-11-21 | |||||
タイトル | ||||||
タイトル | Aβ Secretion and Plaque Formation Depend on Autophagy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nilsson, Per
× Nilsson, Per× Loganathan, Krishnapriya× Sekiguchi, Misaki× Matsuba, Yukio× Hui, Kelvin× Tsubuki, Satoshi× Tanaka, Motomasa× Iwata, Nobuhisa× Saito, Takashi× Saido, Takaomi C. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Alzheimer's disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To investigate the role of autophagy in Aβ pathology invivo, we crossed amyloid precursor protein (APP) transgenic mice with mice lacking autophagy in excitatory forebrain neurons obtained by conditional knockout of autophagy-related protein 7. Remarkably, autophagy deficiency drastically reduced extracellular Aβ plaque burden. This reduction of Aβ plaque load was due to inhibition of Aβ secretion, which led to aberrant intraneuronal Aβ accumulation in the perinuclear region. Moreover, autophagy-deficiency-induced neurodegeneration was exacerbated by amyloidosis, which together severely impaired memory. Our results establish a function for autophagy in Aβ metabolism: autophagy influences secretion of Aβ to the extracellular space and thereby directly affects Aβ plaque formation, a pathological hallmark of AD. | |||||
書誌情報 |
Cell Reports 巻 5, 号 1, p. 61-69, 発行日 2013-10-17 |
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出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 22111247 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.celrep.2013.08.042 | |||||
権利 | ||||||
権利情報 | © 2013 The Authors. Published by Elsevier Inc. All rights reserved. | |||||
権利 | ||||||
権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cell Reports, 5(1), pp.61-69; 2013 |