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Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection
http://hdl.handle.net/10069/34046
http://hdl.handle.net/10069/34046bbb285e7-638a-4b8e-a16b-b09fbad6a9f6
名前 / ファイル | ライセンス | アクション |
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JCV58_635.pdf (663.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-01-09 | |||||
タイトル | ||||||
タイトル | Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biomarker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dengue fever | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dengue hemorrhagic fever | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dengue virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Galectin-9 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chagan-Yasutan, Haorile
× Chagan-Yasutan, Haorile× Ndhlovu, Lishomwa C.× Lacuesta, Talitha Lea× Kubo, Toru× Leano, Prisca Susan A.× Niki, Toshiro× Oguma, Shigeru× Morita, Kouichi× Chew, Glen. M.× Barbour, Jason D.× Telan, Elizabeth Freda O.× Hirashima, Mitsuomi× Hattori, Toshio× Dimaano, Efren M. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Dengue virus (DENV) infection remains a major public health burden worldwide. Soluble mediators may play a critical role in the pathogenesis of acute DENV infection. Galectin-9 (Gal-9) is a soluble β-galactoside-binding lectin, with multiple immunoregulatory and inflammatory properties. Objective: To investigate plasma Gal-9 levels as a biomarker for DENV infection. Study design: We enrolled 65 DENV infected patients during the 2010 epidemic in the Philippines and measured their plasma Gal-9 and cytokine/chemokine levels, DENV genotypes, and copy number during the critical and recovery phases of illness. Results: During the critical phase, Gal-9 levels were significantly higher in DENV infected patients compared to healthy or those with non-dengue febrile illness. The highest Gal-9 levels were observed in dengue hemorrhagic fever (DHF) patients (DHF: 2464. pg/ml; dengue fever patients (DF): 1407. pg/ml; non-dengue febrile illness: 616. pg/ml; healthy: 196. pg/ml). In the recovery phase, Gal-9 levels significantly declined from peak levels in DF and DHF patients. Gal-9 levels tracked viral load, and were associated with multiple cytokines and chemokines (IL-1α, IL-8, IP-10, and VEGF), including monocyte frequencies and hematologic variables of coagulation. Further discriminant analyses showed that eotaxin, Gal-9, IFN-α2, and MCP-1 could detect 92% of DHF and 79.3% of DF, specifically (P < 0.01). Conclusion: Gal-9 appears to track DENV inflammatory responses, and therefore, it could serve as an important novel biomarker of acute DENV infection and disease severity. | |||||
書誌情報 |
Journal of Clinical Virology 巻 58, 号 4, p. 635-640, 発行日 2013-12 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13866532 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jcv.2013.10.022 | |||||
権利 | ||||||
権利情報 | © 2013 The Authors. Published by Elsevier B.V. All rights reserved. | |||||
権利 | ||||||
権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Clinical Virology, 58(4), pp.635-640; 2013 |