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CD105 is a more appropriate marker for evaluating angiogenesis in urothelial cancer of the upper urinary tract than CD31 or CD34
http://hdl.handle.net/10069/34053
http://hdl.handle.net/10069/3405390e819c9-ef45-4625-aa89-0a1c7efda1a5
名前 / ファイル | ライセンス | アクション |
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VirArc463_673.pdf (535.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-01-15 | |||||
タイトル | ||||||
タイトル | CD105 is a more appropriate marker for evaluating angiogenesis in urothelial cancer of the upper urinary tract than CD31 or CD34 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Angiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD105 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD31 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD34 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Urothelial cancer of the upper urinary tract | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyata, Yasuyoshi
× Miyata, Yasuyoshi× Sagara, Yuji× Watanabe, Shin-ichi× Asai, Akihiro× Matsuo, Tomohiro× Ohba, Kojiro× Hayashi, Tomayoshi× Sakai, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Angiogenesis plays an important role in cancer progression in many types of cancer. Evaluation of angiogenesis is often performed, but the optimal methodology for human cancer has not been agreed upon. As adequate evaluation of angiogenesis in cancer tissues might be important for prediction of prognosis and treatment decisions, we evaluated angiogenesis semiquantitatively by assessing microvessel density (MVD) in urothelial cancer of the upper urinary tract (UC-UUT). We compared the performance of three endothelial cell markers (CD31, CD34, and CD105) on formalin-fixed tissues from 122 patients diagnosed with UC-UUT without metastasis. Vascular endothelial growth factor (VEGF)-A expression was also evaluated immunohistochemically. Correlations between MVD with each marker and pT stage, grade, survival, and VEGF-A expression were investigated. Mean (standard deviation) MVD as estimated by immunohistochemical staining with anti-CD31, anti-CD34, and anti-CD105 were 47.1 (17.9)/high-power field (HPF), 70.9 (19.5)/HPF, and 31.2 (16.7)/HPF, respectively. Although all MVDs were significantly associated with pT stage and grade, CD105-MVD showed the strongest association. Similarly, CD105-MVD showed the strongest correlation with VEGF-A expression (r = 0.530, p < 0.001). Although all MVDs were associated with metastasis-free survival and cause-specific survival on univariate analysis, only CD105-MVD was retained as an independent predictor in multivariate analysis including pT stage and grade. CD105-MVD may be the preferred marker for semiquantitative assessment of angiogenesis in patients with UC-UUT. | |||||
書誌情報 |
Virchows Archiv 巻 463, 号 5, p. 673-679, 発行日 2013-11 |
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出版者 | ||||||
出版者 | Springer Verlag | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09456317 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14322307 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00428-013-1463-8 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2013. This article is published with open access at Springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Virchows Archiv, 463(5), pp.673-679; 2013 |