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Effects of photodynamic therapy using talaporfin sodium (Laserphyrin® ) on wound healing in an animal model
http://hdl.handle.net/10069/34057
http://hdl.handle.net/10069/34057348bed0c-10dc-4af0-bad0-2ba670d96c6d
名前 / ファイル | ライセンス | アクション |
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ActMed58_73.pdf (688.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2014-01-17 | |||||
タイトル | ||||||
タイトル | Effects of photodynamic therapy using talaporfin sodium (Laserphyrin® ) on wound healing in an animal model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bile duct carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Photodynamic therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Talaporfin sodium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wound healing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adverse effect | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Murakami, Goushi
× Murakami, Goushi× Nanashima, Atsushi× Nonaka, Takashi× Isomoto, Hajime× Takagi, Katsunori× Arai, Junichi× Hatachi, Go× Abo, Takafumi× Nagayasu, Takeshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Photodynamic therapy (PDT) is an effective laser treatment for locally advanced carcinoma and is promising as neoadjuvant chemotherapy before surgery. The aim of this study was to clarify the adverse effects of PDT using a photosensitizer, talaporfin sodium (Laserphyrin®), for wound healing. Methodology: For PDT, a laser light with a wavelength of 660 nm and a frequency of 10 Hz with a total energy fluency of 60 J/cm2 was used. Macroscopic and histological findings of wound healing after PDT were examined in vivo (4-week-old male BALB/c mice). Results: In Model 1, in which skin was cut at 0, 3, 7 days after PDT (n=3, each), wounds were similarly healed 7 days after cutting in all groups, and regenerating epithelium and the number of fibroblasts on histological findings were not different. In Model 2, in which skin defects were created before or after PDT, the size of the defects was larger at day 7 in the groups with skin defects before or after PDT in comparison with groups with no PDT. However, macroscopic wound healing at day 14 was complete in all groups and there were no significant differences among the groups by this point. Histological findings of skin defects at day 14 showed no significant difference in terms of regenerating epithelium and number of fibroblasts in each group with or without PDT. Conclusions: PDT did not influence wound healing and can be safely applied before surgical therapy. |
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書誌情報 |
Acta medica Nagasakiensia 巻 58, 号 3, p. 73-77, 発行日 2013-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
02 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 58(3), pp.73-77; 2013 |