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Atypical Protein Phosphatases: Emerging Players in Cellular Signaling
http://hdl.handle.net/10069/31911
http://hdl.handle.net/10069/31911e99015b9-f712-4c05-aae9-e22c2c865423
名前 / ファイル | ライセンス | アクション |
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IJMS14_4596.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-05-22 | |||||
タイトル | ||||||
タイトル | Atypical Protein Phosphatases: Emerging Players in Cellular Signaling | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | EYA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mitochondria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PGAM5 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein phosphatase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sts | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sadatomi, Daichi
× Sadatomi, Daichi× Tanimura, Susumu× Ozaki, Kei-ichi× Takeda, Kohsuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It has generally been considered that protein phosphatases have more diverse catalytic domain structures and mechanisms than protein kinases; however, gene annotation efforts following the human genome project appeared to have completed the whole array of protein phosphatases. Ser/Thr phosphatases are divided into three subfamilies that have different structures from each other, whereas Tyr phosphatases and dual-specificity phosphatases targeting Tyr, Ser and Thr belong to a single large family based on their common structural features. Several years of research have revealed, however, the existence of unexpected proteins, designated here as "atypical protein phosphatases", that have structural and enzymatic features different from those of the known protein phosphatases and are involved in important biological processes. In this review, we focus on the identification and functional characterization of atypical protein phosphatases, represented by eyes absent (EYA), suppressor of T-cell receptor signaling (Sts) and phosphoglycerate mutase family member 5 (PGAM5) and discuss their biological significance in cellular signaling. | |||||
書誌情報 |
International Journal of Molecular Sciences 巻 14, 号 3, p. 4596-4612, 発行日 2013-02-26 |
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出版者 | ||||||
出版者 | Multidisciplinary Digital Publishing Institute | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14220067 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ijms14034596 | |||||
権利 | ||||||
権利情報 | © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Molecular Sciences, 14(3), pp.4596-4612; 2013 |