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Phylogeography of Human T-lymphotropic Virus Type 1 (HTLV-1) Lineages Endemic to Japan
http://hdl.handle.net/10069/32042
http://hdl.handle.net/10069/32042681080b8-923a-4352-8735-d788add6ae02
名前 / ファイル | ライセンス | アクション |
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TMH40_117.pdf (708.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-05-29 | |||||
タイトル | ||||||
タイトル | Phylogeography of Human T-lymphotropic Virus Type 1 (HTLV-1) Lineages Endemic to Japan | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Estimation of coalescence time | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HTLV-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Molecular clock | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phylogeography | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Otani, Masashi
× Otani, Masashi× Eguchi, Katsuyuki× Ichikawa, Tatsuki× Takenaka, Takano Kohei× Watanabe, Toshiki× Yamaguchi, Kazunari× Nakao, Kazuhiko× Yamamoto, Taro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We conducted phylogenetic analyses and an estimation of coalescence times for East Asian strains of HTLV-1. Phylogenetic analyses showed that the following three lineages exist in Japan: "JPN", primarily com-prising Japanese isolates; "EAS", comprising Japanese and two Chinese isolates, of which one originated fromChengdu and the other from Fujian; and "GLB1", comprising isolates from various locations worldwide, includinga few Japanese isolates. It was estimated that the JPN and EAS lineages originated as independent lineages approx-imately 3,900 and 6,000 years ago, respectively. Based on archaeological findings, the "Out of Sunda" hypothesiswas recently proposed to clarify the source of the Jomon (early neolithic) cultures of Japan. According to thishypothesis, it is suggested that the arrival of neolithic people in Japan began approximately 10,000 years ago, witha second wave of immigrants arriving between 6,000 and 4,000 years ago, peaking at around 4,000 years ago. Esti-mated coalescence times of the EAS and JPN lineages place the origins of these lineages within this 6,000-4,000 year period, suggesting that HTLV-1 was introduced to Japan by neolithic immigrants, not Paleo-Mongoloids.Moreover, our data suggest that the other minor lineage, GLB1, may have been introduced to Japan by Africansaccompanying European traders several centuries ago, during or after "The Age of Discovery." Thus, the resultsof this study greatly increase our understanding of the origins and current distribution of HTLV-1 lineages in Japanand provide further insights into the ethno-epidemiology of HTLV-1. | |||||
書誌情報 |
Tropical Medicine and Health 巻 40, 号 4, p. 117-124, 発行日 2013-03-13 |
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出版者 | ||||||
出版者 | 日本熱帯医学会 | |||||
出版者別言語 | ||||||
Japanese Society of Tropical Medicine | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13488945 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2149/tmh.2012-15 | |||||
権利 | ||||||
権利情報 | © 2013 Japanese Society of Tropical Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health, 40(4), pp.117-124; 2013 |