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In vitro effects of amodiaquine on paired Schistosoma mansoni adult worms at concentrations of less than 5 μg/mL
http://hdl.handle.net/10069/32117
http://hdl.handle.net/10069/3211735be54e5-0805-4627-bf24-d8b254b967c0
名前 / ファイル | ライセンス | アクション |
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MIOC108_192.pdf (720.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-04 | |||||
タイトル | ||||||
タイトル | In vitro effects of amodiaquine on paired Schistosoma mansoni adult worms at concentrations of less than 5 μg/mL | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Amodiaquine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antimalarial drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antischistosomal drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Schistosoma mansoni | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kato, Kentaro
× Kato, Kentaro× Miura, Mitsumasa× Mitsui, Yoshinori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, the in vitro effects of amodiaquine (AQ) monotherapy on the egg output of paired adult Schistosoma mansoni worms and their survival during in vitro culture were assessed. In addition, the gross morphological alterations of male and female worms caused by AQ were visually observed under a dissecting microscope. AQ significantly reduced the daily egg output of paired adult S. mansoni worms following incubation for 14 days at 1-5 μg/ mL, but not at 0.5 μg/mL, compared with the control group. AQ also reduced the survival of male and female worms at concentrations of 2 and 5 μg/mL, respectively. Moreover, exposure to 5 μg/mL AQ caused severe swelling and/or localisation of black content in the body of all male and female worms within one or two days of incubation; subsequently, shrinkage in the male worms and elongation in the female worms were observed. The initial morphological alterations caused by AQ occurred along the intestinal tract of the male and female worms. To our knowledge, this is the first study to report not only the efficacy of AQ at concentrations lower than 5 μg/mL on paired adult S. mansoni worms, but also the effects of AQ on the intestinal tracts of worms in in vitro culture. | |||||
書誌情報 |
Memórias do Instituto Oswaldo Cruz 巻 108, 号 2, p. 192-196, 発行日 2013-04 |
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出版者 | ||||||
出版者 | Fundacao Oswaldo Cruz | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00740276 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 23579799 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Memórias do Instituto Oswaldo Cruz, 108(2), pp.192-196; 2013 |