WEKO3
アイテム
{"_buckets": {"deposit": "5c5ed5ac-52b2-4023-b6f0-6810be44e43d"}, "_deposit": {"created_by": 2, "id": "7297", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "7297"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00007297", "sets": ["74"]}, "author_link": ["30657", "30651", "30652", "30653", "30655", "30656", "30648", "30650", "30649", "30654"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03-18", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "1472", "bibliographicVolumeNumber": "3", "bibliographic_titles": [{"bibliographic_title": "Scientific Reports"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Accumulation of amyloid-β peptide (Aβ) in the brain is closely associated with cognitive decline in Alzheimer\u0027s disease (AD). Stereotaxic infusion of neprilysin-encoding viral vectors into the hippocampus has been shown to decrease Aβ in AD-model mice, but more efficient and global delivery is necessary to treat the broadly distributed burden in AD. Here we developed an adeno-associated virus (AAV) vector capable of providing neuronal gene expression throughout the brains after peripheral administration. A single intracardiac administration of the vector carrying neprilysin gene in AD-model mice elevated neprilysin activity broadly in the brain, and reduced Aβ oligomers, with concurrent alleviation of abnormal learning and memory function and improvement of amyloid burden. The exogenous neprilysin was localized mainly in endosomes, thereby effectively excluding Aβ oligomers from the brain. AAV vector-mediated gene transfer may provide a therapeutic strategy for neurodegenerative diseases, where global transduction of a therapeutic gene into the brain is necessary.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Scientific Reports, 3, 1472; 2013", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/srep01472", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "20452322", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Iwata, Nobuhisa"}], "nameIdentifiers": [{"nameIdentifier": "30648", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sekiguchi, Misaki"}], "nameIdentifiers": [{"nameIdentifier": "30649", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hattori, Yoshino"}], "nameIdentifiers": [{"nameIdentifier": "30650", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Akane"}], "nameIdentifiers": [{"nameIdentifier": "30651", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asai, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "30652", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ji, Bin"}], "nameIdentifiers": [{"nameIdentifier": "30653", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "30654", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Staufenbiel, Matthias"}], "nameIdentifiers": [{"nameIdentifier": "30655", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Muramatsu, Shin-ichi"}], "nameIdentifiers": [{"nameIdentifier": "30656", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saido, Takaomi C."}], "nameIdentifiers": [{"nameIdentifier": "30657", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "SciRep3_1472.pdf", "filesize": [{"value": "9.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 9600000.0, "url": {"label": "SciRep3_1472.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/7297/files/SciRep3_1472.pdf"}, "version_id": "8c03edb2-545a-44e5-bad1-ff6530365155"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice"}]}, "item_type_id": "2", "owner": "2", "path": ["74"], "permalink_uri": "http://hdl.handle.net/10069/32140", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-06-05"}, "publish_date": "2013-06-05", "publish_status": "0", "recid": "7297", "relation": {}, "relation_version_is_last": true, "title": ["Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice"], "weko_shared_id": -1}
Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
http://hdl.handle.net/10069/32140
http://hdl.handle.net/10069/32140990fd969-5b8f-4097-a059-8818affb19ba
名前 / ファイル | ライセンス | アクション |
---|---|---|
SciRep3_1472.pdf (9.6 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-06-05 | |||||
タイトル | ||||||
タイトル | Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Iwata, Nobuhisa
× Iwata, Nobuhisa× Sekiguchi, Misaki× Hattori, Yoshino× Takahashi, Akane× Asai, Masashi× Ji, Bin× Higuchi, Makoto× Staufenbiel, Matthias× Muramatsu, Shin-ichi× Saido, Takaomi C. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Accumulation of amyloid-β peptide (Aβ) in the brain is closely associated with cognitive decline in Alzheimer's disease (AD). Stereotaxic infusion of neprilysin-encoding viral vectors into the hippocampus has been shown to decrease Aβ in AD-model mice, but more efficient and global delivery is necessary to treat the broadly distributed burden in AD. Here we developed an adeno-associated virus (AAV) vector capable of providing neuronal gene expression throughout the brains after peripheral administration. A single intracardiac administration of the vector carrying neprilysin gene in AD-model mice elevated neprilysin activity broadly in the brain, and reduced Aβ oligomers, with concurrent alleviation of abnormal learning and memory function and improvement of amyloid burden. The exogenous neprilysin was localized mainly in endosomes, thereby effectively excluding Aβ oligomers from the brain. AAV vector-mediated gene transfer may provide a therapeutic strategy for neurodegenerative diseases, where global transduction of a therapeutic gene into the brain is necessary. | |||||
書誌情報 |
Scientific Reports 巻 3, p. 1472, 発行日 2013-03-18 |
|||||
出版者 | ||||||
出版者 | Nature Publishing Group | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20452322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/srep01472 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scientific Reports, 3, 1472; 2013 |