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To this end, we examined the relationship using data from surgical records of 67 patients with hepatocellular carcinoma who underwent hepatectomy. MATERIALS AND METHODS: Liver functional parameters or functional volume was estimated by Tc-GSA scintigraphy and computed tomography volumetry was used to estimate morphological volume. RESULTS: Liver uptake ratio at 15 min (LHL15) was correlated with the indocyanine green retention rate at 15 min (ICGR15; R=-0.608, P\u003c0.01); however, five patients (7.5%) had values outside this correlation. In these patients, LHL15 reflected clinical status and patient outcomes more. Although morphological and functional volumes were well correlated (P\u003c0.01), functional volume was decreased in the diseased liver with portal vein tumor thrombus or portal vein embolization. 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Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma
http://hdl.handle.net/10069/32537
http://hdl.handle.net/10069/32537572be74a-7d3c-426e-99ce-eeab67e72a71
名前 / ファイル | ライセンス | アクション |
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NMC34_478.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-01 | |||||
タイトル | ||||||
タイトル | Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diseased liver | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | functional liver volume | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatocellular carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | portal vein embolization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | technetium-99m galactosyl human serum albumin liver scintigraphy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nanashima, Atsushi
× Nanashima, Atsushi× Abo, Takafumi× Kudo, Takashi× Sakamoto, Ichiro× Hayashi, Hideyuki× Murakami, Goushi× Takeshita, Hiroaki× Hidaka, Shigekazu× Kido, Yasuo× Nagayasu, Takeshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVES: The aim of the study was to clarify the clinical significance of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging in terms of technetium-99m galactosyl human serum albumin (Tc-GSA) scintigraphy. To this end, we examined the relationship using data from surgical records of 67 patients with hepatocellular carcinoma who underwent hepatectomy. MATERIALS AND METHODS: Liver functional parameters or functional volume was estimated by Tc-GSA scintigraphy and computed tomography volumetry was used to estimate morphological volume. RESULTS: Liver uptake ratio at 15 min (LHL15) was correlated with the indocyanine green retention rate at 15 min (ICGR15; R=-0.608, P<0.01); however, five patients (7.5%) had values outside this correlation. In these patients, LHL15 reflected clinical status and patient outcomes more. Although morphological and functional volumes were well correlated (P<0.01), functional volume was decreased in the diseased liver with portal vein tumor thrombus or portal vein embolization. By applying Tc-GSA volumetry, portal pressure and alkaline phosphatase level were correlated with decreased volume of the embolized liver, and platelet count and cholesterol level were correlated with increased volume of the nonembolized liver (P<0.05). By measuring functional volume, four patients who were functionally borderline on the basis of the ICGR15 test safely underwent scheduled major hepatectomy. CONCLUSION: Under the ICGR15 test as the standard for preoperative hepatic function, auxiliary application of LHL15 and functional volumetry provides useful information on hepatocellular carcinoma patients undergoing hepatectomy. | |||||
書誌情報 |
Nuclear Medicine Communications 巻 34, 号 5, p. 478-488, 発行日 2013-05 |
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出版者 | ||||||
出版者 | Lippincott Williams and Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01433636 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/MNM.0b013e32835f945f | |||||
権利 | ||||||
権利情報 | © 2013 Lippincott Williams & Wilkins. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nuclear Medicine Communications, 34(5), pp.478-488; 2013 |